琥珀胆碱的体内过程及其法医毒物分析研究  

Disposition of succinylcholine in vivo and its forensic toxicological approach

作　　者：竺凌[1] 闻俊[1,2] 周婷婷[1,2] 范国荣[1,2] 

机构地区：[1]第二军医大学药学院,上海200433 [2]上海市药物(中药)代谢产物研究重点实验室,上海200433

出　　处：《药物分析杂志》2015年第5期849-855,共7页Chinese Journal of Pharmaceutical Analysis

基　　金：上海市现场物证重点实验室开放课题

摘　　要：琥珀胆碱是临床常用的去极化型肌松药,主要作为手术麻醉诱导剂。近年来该药被非法制成毒针,用来从事违法活动,造成人员琥珀胆碱中毒而死亡。本文综述了琥珀胆碱与代谢产物琥珀单酰胆碱的药代动力学过程,生物样品中琥珀胆碱和琥珀单酰胆碱的前处理以及定性、定量分析方法,对该药法医毒物分析过程中的分析靶标确定、生物检材确定、样品处理与保存等关键问题进行了探讨,对今后琥珀胆碱中毒的司法实践进行了展望。Succinylcholine is a short-acting, depolarizing neuro-muscle blocking agent that is used extensively in clinic, especially for anesthesia. In recent years, some criminals made it into injectable drugs for illegal activities and caused death due to succinylcholine poisoning. This article reviewed the pharmaeokinetics of succinylcholine and its metabolite, succinylmonocholine, as well as the pretreatment of suecinylcholine and suecinylmonocholine in biologi- cal samples and methods for qualitative and quantitative analysis. Some key issues such as choosing the target ana- lytes and biological samples, the conditions of the pretreatment and preservation of samples in the forensic toxicology analysis of sueeinylcholine were further discussed with a prospect of sueeinylcholine poisoning in forensic setting.

关 键 词：琥珀胆碱 琥珀单酰胆碱 药物代谢动力学 毒物分析 液相色谱-质谱联用 

分 类 号：R917[医药卫生—药物分析学]