野生青蒿体内重金属的生物可给性及风险评估  

Bioaccessibility of heavy metal in wild Artemisia annua and its health risk assessment

作　　者：周良云[1] 岳红[2] 李璇[1] 莫歌 康利平[1] 郭兰萍[1] 

机构地区：[1]中国中医科学院中药资源中心道地药材国家重点实验室培育基地,北京100700 [2]长春医学高等专科学校,吉林长春130031

出　　处：《中国中药杂志》2015年第10期1904-1907,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81130070;81325023;81473307);国家科技支撑计划项目(2012BAI29B02;2012BAI28B002)

摘　　要：研究野生青蒿中重金属铜(Cu)、铅(Pb)、砷(As)、镉(Cd)、汞(Hg)的生物可给性,并应用美国环保局提出的靶标危害系数法(THQ)评估其体内重金属含量对暴露人群造成的健康风险。结果显示青蒿中Cu,Pb,As,Cd,Hg的生物可给性分别为0.77,0.66,0.46,0.68,0。通过风险评估模型计算成人和小孩的THQ分别为0.030,0.025。结果表明青蒿中重金属的含量不能被人体完全吸收且实验所用的青蒿重金属含量均处于安全范围内。该文结合重金属生物可给性和健康风险评估模型对野生青蒿中重金属进行安全性评价,为中药材重金属标准的合理制定提供参考依据。In this study, we investigate the bioaccessibility of heavy metals （ Cu, Pb, As, Cd and Hg） in wild Artemisia annua and use target hazard quotients （THQ） proposed by US Environmental Protection Agency to assess the health risk under the heavy metal exposure. The results showed that the bioaccessibility of Cu, Pb, As, Cd and Hg in A. annua are 0. 77, 0.66, 0.46, 0.68 and 0, respectively, and that the value of THQ for adults and children were 0.030 and 0.025 calculated by risk assessment model. The results indicated that the heavy metals in A. annua were not able to be completely absorbed by human body and that their contents were in a safe range. In this study, by combining the bioavailability of heavy metal and health risk assessment, we assessed the security of heavy metals of wild A. annua, which will provide reference for the standard of heavy metals for medicinal materials.

关 键 词：野生青蒿 重金属 生物可给性 风险评估 

分 类 号：S567.219[农业科学—中草药栽培] X173[农业科学—作物学]