血脂正常青年角膜弓患者的低密度脂蛋白亚组分分析  

Analysis of low density lipoprotein subclass in young patients with corneal arcus and normal serum lipids

作　　者：高新晓[1] 郭佳[1] 蔺洁[2] 孟忻[1] 汪军[1] 

机构地区：[1]首都医科大学附属北京安贞医院眼科,北京10029 [2]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所动脉粥样硬化研究室,北京10029

出　　处：《首都医科大学学报》2015年第2期287-290,共4页Journal of Capital Medical University

基　　金：国家自然科学基金(81370443;81170793);中华医学会临床医学科研专项资金项目(14010110548);首都医科大学附属北京安贞医院院长科技发展基金种子基金(2013Z02)~~

摘　　要：目的：精确检测低密度脂蛋白（low density lipoprotein,LDL）的亚组分并评估其中的小而密低密度脂蛋白（small dense LDL,sdLDL）与青年角膜弓（简称青年弓）的相关性。方法入选12例2014年3月至2014年10月就诊于首都医科大学附属北京安贞医院眼科及体检中心的血脂正常的青年弓患者。另外选取12例年龄、性别、吸烟史相匹配的健康对照者。采用Lipoprint LDL System精确检测LDL的亚组分,计算其中的sdLDL占LDL的百分数,即sdLDL比率（ sdLDL%）。采用t检验比较青年弓组与对照组的sdLDL%,再以青年弓为因变量,通过Logistic回归分析（ Backward：LR）评估其相关因素。结果与对照组相比,青年弓组sdLDL%数值偏高[（13.16±6.29）% vs （19.64±6.52）%],差异有统计学意义（P=0.020）。 Logistic回归分析显示：将年龄、LDL校正后,sdLDL%增高和青年弓明显相关（P=0.040）。 sdLDL%是青年弓发生的危险因素（OR=1.49,95%CI：1.01~2.19,P〈0.05）。结论血脂正常青年弓患者的sdLDL%增高,表明其LDL亚组分异常。Objective To exactly analyze low density lipoprotein（ LDL） subclass and examine the association between small dense LDL（ sdLDL） and corneal arcus in young patients. Methods We selected 12 cases of young patients with corneal arcus and normal serum lipids. Another 12 control cases with matched age, gender, smoking were recruited from Beijing Anzhen Hospital between March 2014 and October 2014. LDL particle separation was performed by Lipoprint System： LDL subfractions were obtained and sdLDL proportion（% of sdLDL particles） was calculated. sdLDL% was compared with the Student t test between two groups. Logistic regression analysis was performed to evaluate the correlation between corneal arcus and its related factors. Results SdLDL% was increased in corneal arcus group compared with controls[（19. 64±6. 52）% vs （13. 16±6. 29）%]. The difference between the two groups was significant（P=0. 020）. SdLDL% was significantly associated with corneal arcus（P=0. 040） after controlling for age and LDL. SdLDL%played a role in the development of corneal arcus（OR=1. 49, 95%CI：1. 01-2. 19, P〈0. 05）. Conclusion These findings suggested that young patients with corneal arcus and normal serum lipids had increased level of sdLDL proportion, indicating the abnormality of LDL subclass in such cases.

关 键 词：青年角膜弓 Lipoprint LDL System 小而密低密度脂蛋白 

分 类 号：R446[医药卫生—诊断学]