益肾止衰颗粒治疗慢性肾脏病3～5期的随机对照研究  

Randomized and Controled Study of Treatment on Renal Function in CKD3～5 Stage by Yishenzhishuai Particles

作　　者：吴锋[1] 张新志[1] 王骆冰[1] 陈刚[1] 邵命海[1] 沈沛成[1] 何立群[1] 

机构地区：[1]上海中医药大学附属曙光医院肾内科,国家临床重点专科,国家中医药管理局重点学科,上海市中医临床重点实验室,上海200021

出　　处：《中国中西医结合肾病杂志》2015年第4期311-313,共3页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：国家自然科学基金资助项目(No.81173219);上海市中医药事业发展三年行动计划项目(No.ZYSNXD-CC-YJXYY);上海市卫生局中药新药及院内制剂研发项目(No.2011ZJ008)

摘　　要：目的：观察益肾止衰颗粒对 CKD3～5期患者的临床疗效。方法：单中心的开放性随机对照研究。入选CKD3～5期患者80例，随机分为试验组和对照组。所有入选的患者均予西医基础治疗，试验组在基础治疗上加用益肾止衰颗粒，对照组在基础治疗上加用尿毒清颗粒，疗程24周，每8周观察治疗后eGFR、Scr、BUN、UA、Alb变化。结果：两组的总体疗效相当，组间比较eGFR、Scr、BUN、UA、Alb在各个随访期均差异无统计学意义（ P＞0．05）。两组的eGFR在治疗前后及组间比较都差异无统计学意义（ P＞0．05），但益肾止衰颗粒组在治疗期间相对保持稳定，而尿毒清颗粒组呈现下降的趋势。益肾止衰颗粒组的Alb有升高的趋势，在24周后差异有统计学意义（ P〈0．05）。结论：益肾止衰颗粒具有一定的延缓慢性肾衰竭进展的作用，其疗效与尿毒清颗粒相当，并且能改善慢性肾衰竭患者的营养不良，在卫生经济学上更具有优势。Objective：To observe the effect of Yishenzhishuai particles on patients of chronic kidney disease（ CKD）3～4 stage. Methods：An open randomized controlled single-center study. Total 80 patients of CKD 3～4 stage were randomized divided into test group and control group. All patients were accepted the foundation of Western medicine treatment,the patients in test group were plused with Yishenzhishuai particles,and the patients in control group were plused with Niaoduqing particles. The course of treatment was 24 weeks. Observed the changes of estimate glomerular filtration rate（ eGFR）,serum creatinine（ Scr）,blood urea ni-trogen（ BUN）,Uric acid（ UA）and plasma albumin（ Alb）every 8 weeks. Results：Both groups had similar overall efficacy,eGFR, Scr,BUN,UA,and Alb were not significant difference between the groups for each follow-up period（P〉0. 05）. eGFR was no sig-nificant difference between before and after treatment and comparison groups（P〉0. 05）. But eGFR in test group remained relatively stable during the treatment,while it showed a downward trend in Niaoduqing particles. Alb in test group showers a tend to increase, it has statistically significant after 24 weeks（P〈0. 05）. Conclusion：Yishenzhishuai particles has the effect of a certain decay delay progression of chronic renal failure,the efficacy was quite with Niaoduqing particles. Yishenzhishuai particles can improve malnutri-tion in patients with chronic renal failure,and has more advantages on health economics.

关 键 词：益肾止衰颗粒 尿毒清颗粒 慢性肾衰竭 随机对照研究 

分 类 号：R277.5[医药卫生—中医学]