Paternally contributed centrioles exhibit exceptiona persistence in C. elegans embryos  

作　　者：Femando R Balestra Lukas von Tobel Pierre Gonczy 

机构地区：[1]Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology (EPFL) Lausanne, Switzerland

出　　处：《Cell Research》2015年第5期642-644,共3页细胞研究（英文版）

摘　　要：Dear Editor, The two gametes make different contributions to the zygote at fertilization. Although both gametes contribute genetic material, in most animal species the oocyte do- nates the bulk of cytoplasmic constituents and cellular organelles, including mitochondria, whereas the sperm donates two centrioles. Centrioles are microtubule-based organelles that serve as templates for the axoneme of cilia and flagella across eukaryotic evolution, and as plat- forms for centrosome assembly in most animal cells [ 1 ]. How long the two centrioles contributed by the sperm persist in the developing embryo is not known in any system. More generally, although centrioles are reputed to be stable structures, the extent to which their constit- uents persist over several cell cycles has been scarcely studied. Two instances of centriolar components being stable for one （a/J3 tubulin in mammalian cells） or two （SAS-4 in C. elegans） cell cycles have been reported [2- 4], but whether these and other centriolar components remain stable for more cell cycles is not known.

关 键 词：中心粒 线虫 胚胎 哺乳动物细胞 展览 父系 细胞周期 微管蛋白 

分 类 号：Q244[生物学—细胞生物学] Q959.17