RFA联合TACE治疗合并肝硬化的早期肝细胞肝癌的疗效研究  

Effect of RFA combined with TACE for treatment of early hepatocellular carcinoma with liver cirrhosis

作　　者：王瑜[1] 马宽生[1] 陈健[1] 宋举贤[1] 

机构地区：[1]第三军医大学西南医院全军肝胆外科研究所西南肝胆外科医院,重庆400038

出　　处：《局解手术学杂志》2015年第3期273-276,共4页Journal of Regional Anatomy and Operative Surgery

基　　金：重庆市自然科学基金项目(2008BB5029)

摘　　要：目的评估射频消融术(RFA)联合肝动脉化疗栓塞术(TACE)与单独射频消融术治疗合并肝硬化的早期肝细胞癌(HCC)的疗效。方法回顾性分析2008年1月至2013年12月在我院行RFA(n=53)和RFA+TACE(n=51)患者的临床资料,对2组患者人口统计学资料、手术过程、术后并发症、术后恢复情况及随访情况进行比较。结果随访(37.6±12.3)个月,76例生存,38例死亡。RFA+TACE组和RFA组的1年、3年、5年无瘤生存率分别为75.4%、47.3%、32.6%和63.1%、37.2%、22.4%。RFA+TACE组和RFA组的1年、3年、5年总生存率分别为96.5%、78.7%、65.9%和94.3%、75.6%、62.3%。结论对于合并肝硬化早期肝癌患者,RFA+TACE治疗比单独使用RFA治疗具有更高的无瘤生存率,而总体生存率无差异。Objective To assess the effect of radiofrequency ablation （ RFA） combined with transcatheter hepatic arterial chemoemboli-zation （ TACE） and radiofrequency ablation alone for the treatment of early hepatocellular carcinoma （ HCC） with liver cirrhosis. Methods The data of all the patients that were given RFA＋TACE （n=51） and RFA （n=53） treatments in our hospital from January 2008 to De-cember 2013 were analyzed. The demographic data,process of operation,postoperative complications,postoperative recovery and follow-up of the patients in two groups were carefully compared. Results The average follow-up time was （37. 6 ± 20. 7）months,38 cases were dead and 76 cases were survival. The overall survival rates of 1 years,3 years,5 years after operation were respectively 96. 5%,78. 7%,65. 9% in RFA＋TACE group and 94. 3%,75. 6%,62. 3% in RFA group. Tumor-free survival rates of 1 years,3 years,5 years were 75. 4%,47. 3%, 32. 6% in RFA＋TACE group,and 63. 1%,37. 2%,22. 4% in RFA group. Conclusion For patients with early hepatocellular carcinoma with liver cirrhosis,RFA combined with TACE have higher tumor free survival rate than RFA alone in the treatment of early hepatocellular＆nbsp;carcinoma,but no difference in overall survival rate. The results still need to be validated by prospectively randomized controlled trials.

关 键 词：射频消融术 肝动脉化疗栓塞术 早期肝癌 肝硬化 

分 类 号：R657.3[医药卫生—外科学] R605[医药卫生—临床医学]