异丙酚和咪达唑仑单用于中心静脉穿刺的镇静效果研究  

Effects of propfol and midazolam for sedation effect of central venous puncture

作　　者：周鹏[1] 周林[2] 杨小莉[3] 罗玥姮[4] 周霞[5] 

机构地区：[1]四川大学华西医院急诊科,四川成都610041 [2]解放军第37医院药械科,四川雅安625000 [3]解放军第37医院骨胸外科,四川雅安625000 [4]解放军第37医院神经外科,四川雅安625000 [5]雅安市第二人民医院医务科,四川雅安625000

出　　处：《局解手术学杂志》2015年第3期317-319,共3页Journal of Regional Anatomy and Operative Surgery

摘　　要：目的探讨异丙酚和咪达唑仑单用于急诊中心静脉穿刺的效果和对呼吸循环指标的影响。方法 100名需行中心静脉穿刺的患者按照使用麻醉药物的不同分为异丙酚组(50例)和咪达唑仑组(50例),给予不同的剂量输入,用镇静量表(RSS)进行评估,以患者镇静起效时间和意识恢复时间为依据给药并实施中心静脉穿刺。结果异丙酚组与咪达唑仑组镇静过程中,对患者的呼吸循环影响差异无统计学意义。异丙酚组和咪达唑仑组达到RSS-5的时间相比(P>0.05),无统计学意义;意识恢复到RSS-2的时间各组相比(P<0.01),有显著差异。结论异丙酚和咪达唑仑单用均能快速达到安全深静脉穿刺的镇静深度,对呼吸循环系统影响轻微,无严重不良反应发生,但异丙酚镇静起效时间意识恢复时间明显缩短。Objective To compare the effect of propofol and Midazolam for the vein puncture and indicators of respiratory cycle in the e-mergency center. Methods According to different anaesthetic,100 patients who needed for central venepuncture in patients,were randomly divided into Propofol group （50 cases） and Midazolam group （50 cases）,given different dose input,and evaluated by RSS（Ramsay Sedation Scale,RSS） . In terms of the onset time and recovery time of consciousness,the central venous puncture were performed with all the patients. Results There was no significant difference in the process of sedation effect on respiration and circulation of the patients between 2 groups. And the differences between 2 groups with the time of reaching RSS-5 were no statistical significance,while the differences of consciousness recovery time between 2 groups were statistical significance. Conclusion The appropriate dosage and velocity of Propofol and Midazolam can quickly achieve central vein puncture,with slight influence on respiratory and circulatory system and no serious adverse reaction. But the onset time and consciousness recovery time of the Propofol which has a good controllability was shorter than those of Midazolam.

关 键 词：异丙酚 咪达唑仑 镇静 中心静脉穿刺 

分 类 号：R961[医药卫生—药理学] R459[医药卫生—药学]