呼末二氧化碳指导新西兰大白兔机械通气的研究  

Leading effect of P_(ET)CO_2 on mechanical ventilation in New Zealand white rabbits

作　　者：杨俊哲[1] 张燕辉[1] 吴明春[1] 陶军[1] 宋晓阳[1] 罗中兵[1] 

机构地区：[1]广州军区武汉总医院麻醉科,湖北武汉430070

出　　处：《局解手术学杂志》2015年第3期327-329,共3页Journal of Regional Anatomy and Operative Surgery

摘　　要：目的：观察持续呼末二氧化碳分压（ PET CO2）监测对新西兰大白兔机械通气的指导作用,探讨新西兰大白兔合理的机械通气方法,建立血流动力学、血气、血糖和电解质等参数,为医学动物实验研究提供参考。方法新西兰大白兔31只,麻醉后行气管切开插管、机械通气,呼吸次数40次/分,调整潮气量使 PET CO2稳定在29 mmHg。持续监测有创血压（ IBP）、心电图（ ECG）和呼吸末二氧化碳分压。股动脉置管行血气分析、电解质、血红蛋白和血糖检验。结果维持PET CO2在29 mmHg时,PH值（7.42±0.07）,95%可信区间（7.40~7.45）；PaCO2（38.5±5.8） mmHg,95%可信区间（36.4~40.6） mmHg；BE （1.45±2.80） mmol/L,95%可信区间（0.43~2.48） mmHg。结论使用PETCO2监测能精确指导新西兰大白兔机械通气,减少实验时机械通气设置错误。Objective To observe the leading effect of end-tidal pressure of carbon dioxide in artery （ PET CO2 ） on mechanical ventila-tion in New Zealand white rabbits, and to establish parameters for medical animal experiments in terms of hemodynamics, blood gas, blood glucose, electrolyte. Methods 31 anesthetized New Zealand rabbits were practiced tracheostomy tube and mechanical ventilation. Respira-tion rate was 40 breaths/min and tidal volume was adjusted so that PET CO2 was 29 mmHg. Invasive blood pressure, electrocardiogram and PET CO2 were monitored. Blood gas analysis, electrolyte, hemoglobin and blood glucose were tested. Results When PET CO2 was maintained at 29 mmHg, the results were as follows：PH （7.42 ±0.07）, 95% confidenceinterval （7.40~7.45）;PaCO2（38.5 ±5.8） mmHg, 95%confidenceinterval （36. 4~40. 6） mmHg;BE （1. 45 ± 2. 80） mmol/L,95% confidenceinterval （0. 43~2. 48） mmHg. Conclusion Moni-toring of PET CO2 is good to guide mechanical ventilation in New Zealand white rabbits.

关 键 词：兔 呼末二氧化碳分压 机械通气 电解质 血气分析 血流动力学 

分 类 号：R322[医药卫生—人体解剖和组织胚胎学]