氟代脱氧葡萄糖正电子发射断层扫描/CT显像在不明原因发热病因诊断的价值  

The Role of 18F-FDG PET/CT in the Diagnosis of Fever of Unknown Origin

作　　者：胡霜[1] 沈国华[1] 郭佳[1] 吉婷[1] 刘斌[1] 匡安仁[1] 

机构地区：[1]四川大学华西医院核医学科,成都610041

出　　处：《华西医学》2015年第5期919-923,共5页West China Medical Journal

基　　金：国家自然科学基金(81071184);卫生部行业科研专项基金(201002002)~~

摘　　要：目的探讨氟代脱氧葡萄糖(18F-FDG)正电子发射断层扫描(PET)/CT显像在不明原因发热(FUO)患者病因诊断的价值。方法回顾性分析2011年1月-2013年10月32例FUO患者18F-FDG PET/CT全身显像结果和临床资料,结果判断采用公认的临床标准。结果 18F-FDG PET/CT显像能精确找到17例(53.1%)FUO患者发热病因,对25例(78.1%)患者的诊断有帮助。共有20例患者得到明确诊断,其中感染性炎症8例,非感染性炎症2例,恶性肿瘤8例,其他2例。18F-FDG PET/CT显像对病因判断的真阳性、假阳性、真阴性、假阴性、灵敏度和特异度分别为17.0%、4.0%、8.0%、3.0%、85.0%和66.7%。结论 18F-FDG PET/CT显像对协助不明原因发热患者的病因寻找具有较高的价值。Objective To investigate the diagnostic value of 18F-FDG PET/CT scan for fever of unknown origin. Methods The 18F-FDG PET/CT scan results and clinical data were analyzed retrospectively in 32 patients with fever of unknown origin examined between January 2011 and October 2013. Final diagnoses were determined with recognized diagnostic standard. Results 18F-FDG PET/CT scan was able to detect the cause of fever precisely in 53.1% （n=17） of the patients and was helpful in 25 patients （78.1%）. The final cause of fever was determined in 20 patients, including infection （40%）, malignancy （10%）, non-infectious inflammatory disease （40%） and miscellaneous causes （10%）. True positive, false positive, true negative and false negative rate of the modality were 17.0%, 4.0%, 8.0% and 3.0%; and the sensitivity and specificity were 85.0% and 66.7%. Conclusion18F-FDG PET/CT scan plays an important role in the diagnosis of fever of unknown origin.

关 键 词：氟代脱氧葡萄糖正电子发射断层扫描/CT 不明原因发热 诊断 感染 肿瘤 

分 类 号：R441.3[医药卫生—诊断学] R817.4[医药卫生—临床医学]