新疆维吾尔族银屑病患者皮损中p15、p16、p21蛋白表达及意义  

Expression and significance of p15, p16, p21 in Uygur patients with psoriasis in Xinjiang

作　　者：王慧琴[1] 刘新梅[2] 吴秀娟[2] 吴卫东[1] 

机构地区：[1]新疆维吾尔自治区人民医院临床医学研究中心,乌鲁木齐830001 [2]新疆维吾尔自治区人民医院皮肤性病科,乌鲁木齐830001

出　　处：《中国医师杂志》2015年第5期692-694,共3页Journal of Chinese Physician

基　　金：新疆维吾尔自治区人民医院基金资助项目（20120106）

摘　　要：目的 通过检测p15、p16、p21在维吾尔族银屑病患者皮损中的表达,探讨其蛋白表达在银屑病发病中的意义.方法 应用免疫组化方法检测新疆维吾尔族银屑病患者皮损及维吾尔族正常皮肤组织中的蛋白表达情况.结果 维吾尔族银屑病患者皮损中p16基因的阳性表达率为12.5％,显著低于正常组中的阳性表达率（66.67％）,差异有统计学意义（P＜0.05）;p15、p21基因在维吾尔族健康人群和银屑病患者皮损中的阳性表达比较差异均无统计学意义（P＞0.05）.结论 维吾尔族银屑病发病可能与p16蛋白表达异常有关.Objective To investigate the expressions of p15,p16,and p21 in skin of uygur patients with psoriasis and its significance in the development of psoriasis.Methods The expressions of p15,p16,and p21 were studied with immunohistochemical method in the Xinjiang Uygur psoriatic and normal Uygur skins.Results The positive expression rate of p16 gene was 12.5% in skin lesions of patients with psoriasis Uygur,and 66.67% in the normal group.The positive expressions of p15,and p21 genes in skin lesions of patients with psoriasis and healthy Uygur population were higher.Conclusions There is a significant correlation between the development of uygur psoriasis vulgaris and abnormal expression of p16.

关 键 词：银屑病/病理学/代谢 皮肤/病理学/代谢 基因 p16 癌基因蛋白质p21(ras)/代谢 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]