Effect of Shenzhu Guanxin Recipe (参术冠心方)on Patients with Angina Pectoris after Percutaneous Coronary Intervention:A Prospective, Randomized Controlled Trial  

作　　者：徐丹苹 吴焕林 蓝涛华 王侠 盛小刚 林宇 李松 郑朝阳 

机构地区：[1]Cardiovascular Department,Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangdong Provincial Academy of Chinese Medical Sciences [2]Postdoctoral Mobile Research Station,Guangzhou University of Traditional Chinese Medicine [3]Cardiovascular Department of Ershadao Hospital,Guangdong Provincial Hospital of Traditional Chinese Medicine [4]Cardiac Surgeon Department of University Town Hospital,Guangdong Provincial Hospital of Traditional Chinese Medicine [5]Cardiovascular Department of Fangcun Hospital,Guangdong Provincial Hospital of Traditional Chinese Medicine [6]Cardiovascular Department of University Town Hospital,Guangdong Provincial Hospital of Traditional Chinese Medicine

出　　处：《Chinese Journal of Integrative Medicine》2015年第6期408-416,共9页中国结合医学杂志（英文版）

基　　金：Supported by the National Key Technology Research and Development Program of the Ministry of Science and Technology of China(No.2001BAI10B02);Science and Technology Planning Project of Guangdong Province,China(No.2012A032500017)

摘　　要：Objective： To evaluate the efficacy and safety of a combination therapy using Chinese medicine （CM） Shenzhu Guanxin Recipe （参术冠心方, SGR） and standard Western medicine treatment （SWMT） in patients with angina pectoris after percutaneous coronary intervention （PCI）. Methods： Double-blind randomized controlled trial was used in this experimental procedure. One hundred and eighty-seven patients with coronary heart disease receiving SWMT after PCI were randomly assigned to the treatment （SGR） and control （placebo） groups. Outcome measures including angina pectoris score （APS）, CM symptom score, and Seattle Angina Questionnaire （SAQ） score were evaluated in 1, 2, 3 and 12 months, and the death rate, restenosis and other emergency treatments were observed. The mixed-effects models were employed for the data analysis. Results： In the treatment group, a larger within-treatment effect size （d=1.74） was found, with a 76.7% reduction in APS from pretreatment to 12-month follow-up assessment compared with the control group （d=0.83, 53.8% symptom reduction）; between- treatment （BT） effect size was d=0.66. CM symptom scores included an 18.3% reduction in the treatment group （d=0.46）, and a 16.1% decrease in the control group （d=0.31）; d=0.62 for BT effect size. In regard to scores of SAQ, the BT effect size of cognition level of disease was larger in the treatment group （d=0.63）, followed by the level of body limitation of activity （d=0.62）, condition of angina pectoris attacks （d=0.55）, satisfaction level of treatments （d=0.31）, and steady state of angina pectoris （d=0.30）. Two cardiovascular related deaths and one incidental death were recorded in the control and treatment groups, respectively. No significant difference in any cardiovascular event （including death toll, frequency of cardiovascular hospitalization or emergency room visits） was found between the two groups. Conclusion： The combination therapy of SGR and SWMT is effectivObjective： To evaluate the efficacy and safety of a combination therapy using Chinese medicine （CM） Shenzhu Guanxin Recipe （参术冠心方, SGR） and standard Western medicine treatment （SWMT） in patients with angina pectoris after percutaneous coronary intervention （PCI）. Methods： Double-blind randomized controlled trial was used in this experimental procedure. One hundred and eighty-seven patients with coronary heart disease receiving SWMT after PCI were randomly assigned to the treatment （SGR） and control （placebo） groups. Outcome measures including angina pectoris score （APS）, CM symptom score, and Seattle Angina Questionnaire （SAQ） score were evaluated in 1, 2, 3 and 12 months, and the death rate, restenosis and other emergency treatments were observed. The mixed-effects models were employed for the data analysis. Results： In the treatment group, a larger within-treatment effect size （d=1.74） was found, with a 76.7% reduction in APS from pretreatment to 12-month follow-up assessment compared with the control group （d=0.83, 53.8% symptom reduction）; between- treatment （BT） effect size was d=0.66. CM symptom scores included an 18.3% reduction in the treatment group （d=0.46）, and a 16.1% decrease in the control group （d=0.31）; d=0.62 for BT effect size. In regard to scores of SAQ, the BT effect size of cognition level of disease was larger in the treatment group （d=0.63）, followed by the level of body limitation of activity （d=0.62）, condition of angina pectoris attacks （d=0.55）, satisfaction level of treatments （d=0.31）, and steady state of angina pectoris （d=0.30）. Two cardiovascular related deaths and one incidental death were recorded in the control and treatment groups, respectively. No significant difference in any cardiovascular event （including death toll, frequency of cardiovascular hospitalization or emergency room visits） was found between the two groups. Conclusion： The combination therapy of SGR and SWMT is effectiv

关 键 词：Shenzhu Guanxin Recipe angina pectoris percutaneous coronary intervention coronary heart disease randomized controlled trial Chinese medicine 

分 类 号：R541.4[医药卫生—心血管疾病]