慢性心力衰竭患者血尿酸水平和房颤的关系  

Relationship of serum uric acid with atrial fibrillation in patients with chronic heart failure

作　　者：肖婷[1] 张献斌[1] 罗磊[1] 杨娜[1] 梁晗[1] 许新录[1] 

机构地区：[1]商洛市中心医院心血管内科,商洛726000

出　　处：《中华老年多器官疾病杂志》2015年第4期297-300,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

摘　　要：目的：分析慢性心力衰竭（CHF）患者血尿酸（SUA）水平与房颤（AF）的关系。方法回顾性地分析2010年1月至2014年2月期间在商洛市中心医院心血管内科住院的218例CHF患者的人口学资料、既往相关病史、血液生化指标、超声心动图及颈部血管超声结果。根据是否AF将218例患者分为AF组和窦性心律组。结果218例患者中，有49例合并AF，169例为窦性心律，AF发生率为22.5%。与窦性心律组相比，SUA水平在AF组明显升高。AF组的年龄比窦性心律组更高[（64.32±9.87） vs （56.78±10.14）岁，P＜0.05。]；射血分数前者比窦性心律组低，差异有统计学意义（P＜0.05）；而包括左心房内径、左心室舒张末内径、左心室收缩末内径等在内的超声心动图参数，AF组比窦性心律组高；颈动脉内膜中层厚度AF组也明显高于窦性心律组（P＜0.05）。多因素logistic回归分析显示，SUA水平为发生AF的独立危险因素。结论 AF组患者有更高的SUA水平和更差的心功能。Objective To analyze the association of serum uric acid （SUA） with atrial fibrillation （AF） in the patients with chronic heart failure （CHF）. Methods A total of 218 CHF patients admitted in our department from January 2010 to February 2014 were enrolled in this study. Their demographic data, medical history, blood biochemical parameters, ultrasonic echocardiogram and cervical vascular ultrasound results were collected and retrospectively analyzed. The patients were divided into 2 groups, that is, normal sinus rhythm group and AF group. Results Of 218 CHF patients, 49 patients （22.5%） had AF, and 169 patients were in normal sinus rhythm. SUA was significantly higher in the patients with AF than those with normal sinus rhythm （P〈0.05）. AF patients were older than those with normal sinus rhythm [（64.32±9.87） vs （56.78±10.14） years, P〈0.05], had lower ejection fraction （EF, P〈0.05）, higher values in echocardiographic parameters, such as left atrium diameter, left ventricular end-diastolic diameter, and left ventricular end systolic diameter, and obviously larger intimal medial thickness （P〈0.05）. Multivariate logistic regression analysis showed that SUA was the independent risk factor for AF. Conclusion AF patients have significantly higher SUA levels, and poorer heart function.

关 键 词：心力衰竭 尿酸 心房颤动 

分 类 号：R541.61[医药卫生—心血管疾病]