重症肌无力症-药关系的典型相关分析研究  

Canonical Correlation Analysis of Relationship between Drugs and Symptoms of Myasthenia Gravis

作　　者：刘凌云[1] 

机构地区：[1]广州中医药大学,广东广州510405

出　　处：《山东中医药大学学报》2015年第3期210-214,共5页Journal of Shandong University of Traditional Chinese Medicine

摘　　要：目的 :运用数理统计方法 ,分析病症特点与用药规律。方法 :采用SAS 8.0软件编程,调用典型相关运算模块,将症状作为第一组变量,中药作为第二组变量,求出典型变量对和典型相关系数,运用典型相关分析统计方法探讨药物群与症状群的对应关系。结果:吞咽困难与苍术呈正相关关系,左眼睑下垂与升麻呈正相关、与柴胡呈负相关关系,肌无力出现脾虚便溏与黄芩呈正相关关系。结论:药物对症治疗的新功效有待进一步挖掘;重症肌无力出现危象时,可考虑加重升提举陷药物的使用;重症肌无力出现脾虚下陷证,要慎用苦寒但不忌寒药;兼症用药规律尚不明显。Objective：Mathematical statistics methods were adopted to analyze the disease and symptom characteristics and medication rules. Methods：The SAS 8.0 software was used to program and the module of canonical correlation operation was called. The symptoms were variables in No.1 group and the Chinese medicines were variables in NO.2 group. The canonical variable pairs and canonical correlation coefficient were calculated. The correspondence between medicine cluster and symptom cluster was explored by canoni- cal correlation analysis. Results ：Dysphagia was positively correlated with rhizoma atractyloids. Ptosis of left eyelid was positively correlated with cimicifuga foetida and negatively correlated with radix bupleuri. Spleen deficiency and loose stool caused by myasthenia gravis was positively correlated with radix scutellariae. Conclusion：Further mining of new effects of medicines on treatment according to symptoms is needed. When myasthenia gravis crisis appears,medicines for lifting can be increased;when syndrome of spleen deficiency and sinking appears,medicines of bitter taste and cold nature should be used with caution,but the cold medicines need not to be avoided. Medication rules of secondary symptoms are not obvious.

关 键 词：重症肌无力 症药 典型相关分析 

分 类 号：R277.746.1[医药卫生—中医学]