Design,synthesis,and insecticidal bioactivities evaluation of pyrrole-and dihydropyrrole-fused neonicotinoid analogs containing chlorothiazole ring  

作　　者：Hong-Feng Shen Xi Chen Pin Liao Xu-Shen Shao Zhong Li Xiao-Yong Xu 

机构地区：[1]Shanghai Key Laboratory of Chemical Biology,School of Pharmacy,East China University of Science and Technology [2]Shanghai Collaborative Innovation Center for Biomanufacturing Technology

出　　处：《Chinese Chemical Letters》2015年第5期509-512,共4页中国化学快报（英文版）

基　　金：supported by National Key Technology R&D Program of China(No.2011BAE06B01)

摘　　要：Chlorothiazole ring, as a substituted heterocycle, frequently occurred in structures of various insecticides, and brought positive effect on bioactivity. In purpose to find novel neonicotinoids, a series of pyrrole- and dihydropyrrole-fused neonicotinoid analogs containing chlorothiazole ring were synthesized for the first time. Results of the following biological assays showed that compounds Sa-c achieved good insecticidal activity against Aphis craccivora, and compound Sh exhibited good activity against Nilaparvata lugens.Chlorothiazole ring, as a substituted heterocycle, frequently occurred in structures of various insecticides, and brought positive effect on bioactivity. In purpose to find novel neonicotinoids, a series of pyrrole- and dihydropyrrole-fused neonicotinoid analogs containing chlorothiazole ring were synthesized for the first time. Results of the following biological assays showed that compounds Sa-c achieved good insecticidal activity against Aphis craccivora, and compound Sh exhibited good activity against Nilaparvata lugens.

关 键 词：Neonicotinoid Pyrrole Dihydropyrrole Insecticidal activity 

分 类 号：TQ453[化学工程—农药化工]