Microwave-assisted efficient synthesis of azlactone derivatives using 2-aminopyridine-functionalized sphere SiO_2 nanoparticles as a reusable heterogeneous catalyst  

作　　者：Akbar Mobinikhaledi Hassan Moghanian Samira Pakdel 

机构地区：[1]Department of Chemistry,Faculty of Science,Arak University [2]Department of Chemistry,Dezful Branch,Islamic Azad University

出　　处：《Chinese Chemical Letters》2015年第5期557-563,共7页中国化学快报（英文版）

基　　金：financial support from the Research Council of Arak University

摘　　要：In the present work, the highly efficient Erlenmeyer synthesis of azlactones catalyzed by 2- aminopyridine, supported on nano-sphere Si02 is reported. First, the silica nanoparticles were modified with triethoxysilylpropyl chloride and then 2-aminopyridine was attached to the support via covalent linkages. This new heterogenized catalyst was used for efficient microwave-assisted synthesis of azlactone derivatives with Ac20 as a condensing agent under solvent-free conditions. The present method offers advantages including high yields, short reaction times and simple work-up. Also, the catalyst can be easily recycled and reused several times, which makes this method attractive, economic and environmentally-benign.In the present work, the highly efficient Erlenmeyer synthesis of azlactones catalyzed by 2- aminopyridine, supported on nano-sphere Si02 is reported. First, the silica nanoparticles were modified with triethoxysilylpropyl chloride and then 2-aminopyridine was attached to the support via covalent linkages. This new heterogenized catalyst was used for efficient microwave-assisted synthesis of azlactone derivatives with Ac20 as a condensing agent under solvent-free conditions. The present method offers advantages including high yields, short reaction times and simple work-up. Also, the catalyst can be easily recycled and reused several times, which makes this method attractive, economic and environmentally-benign.

关 键 词：Nano-sphere silica Azlactone Heterogeneous catalyst Erlenmeyer synthesis Microwave irradiation 

分 类 号：O643.36[理学—物理化学] O621.3[理学—化学]