Potential anti-tubercular agents:Hexahydro-3-phenyl indazol-2-yl(pyridin-4-yl)methanones from anti-tubercular drug isoniazid and bis(substituted-benzylidene)cycloalkanones  

作　　者：Ayyakannu Arumugam Napoleon Fazlur-Rahman Nawaz Khan Euh Duck Jeong Eun Hyuk Chung 

机构地区：[1]Organic and Medicinal Chemistry Research Laboratory,Organic Chemistry Division,School of Advanced Sciences,VIT-University [2]Korea Basic Science Institute,Busan Center

出　　处：《Chinese Chemical Letters》2015年第5期567-571,共5页中国化学快报（英文版）

基　　金：VIT University for providing us with research funding and laboratory facilities;Maratha Mandal Dental College,Belgaum for biological screening support

摘　　要：A series of indazol-2-yl（pyridin-4-yl）methanones, 4 were acquired from 2,6-bisbenzylidene cyclohex- anones, 3 and anti-tubercular drug （isoniazid）, and their anti-tubercular impacts were screened. Among the test compounds used against Mycobacterium tuberculosis H37 Ra cell line in the microplate alamar blue assay, the compounds 4g-j revealed moderate anti-tubercular activity with MIC 12.5 μg/mL, comparable to standard drugs （streptomycin, MIC, 6.25 μg/mL, pyrazinamide, isoniazid and ciprofloxacin with MICs of 3.125 μg/mL）.A series of indazol-2-yl（pyridin-4-yl）methanones, 4 were acquired from 2,6-bisbenzylidene cyclohex- anones, 3 and anti-tubercular drug （isoniazid）, and their anti-tubercular impacts were screened. Among the test compounds used against Mycobacterium tuberculosis H37 Ra cell line in the microplate alamar blue assay, the compounds 4g-j revealed moderate anti-tubercular activity with MIC 12.5 μg/mL, comparable to standard drugs （streptomycin, MIC, 6.25 μg/mL, pyrazinamide, isoniazid and ciprofloxacin with MICs of 3.125 μg/mL）.

关 键 词：Benzylidene cyclohexanones Hexahydro-3-phenyl indazol-2-yl （pyridin- 4-yl）methanones lsoniazid Anti-tubercular activity 

分 类 号：TQ460.1[化学工程—制药化工]