Alumina-supported heteropoly acid:An efficient catalyst for the synthesis of azaarene substituted 3-hydroxy-2-oxindole derivatives via C(sp^3)-H bond functionalization  

作　　者：Shuang-Hong Hao Xue-Yan Zhang Dao-Qing Dong Zu-Li Wang 

机构地区：[1]College of Chemistry and Pharmaceutical Sciences,Qingdao Agricultural University

出　　处：《Chinese Chemical Letters》2015年第5期599-602,共4页中国化学快报（英文版）

基　　金：Financial support from the National Natural Science Foundation of China(No.21402103);the research fund of Qingdao Agricultural University's High-level Person(No.631303);the Scientific Research Foundation of Shandong Province Outstanding Young Scientist Award(No.BS2013YY024) were gratefully acknowledged

摘　　要：A method of C（sp^3）-H bond functionalization of methyl azaarenes catalyzed by alumina-supported heteropoly acid and addition to isatins was developed. This transformation could be used for the synthesis of biologically important 3-hydroxy-2-oxindole derivatives in good to excellent yields and the catalyst could be reused for six times without significant decrease in activity.A method of C（sp^3）-H bond functionalization of methyl azaarenes catalyzed by alumina-supported heteropoly acid and addition to isatins was developed. This transformation could be used for the synthesis of biologically important 3-hydroxy-2-oxindole derivatives in good to excellent yields and the catalyst could be reused for six times without significant decrease in activity.

关 键 词：Alumina-supported heteropoly acid C（sp^3）-H functionalization Azaarenes 3-Hydroxy-2-oxindoles Isatin 

分 类 号：O643.36[理学—物理化学]