Electroanalytical method for determination of shikonin based on the enhancement effect of cyclodextrin functionalized carbon nanotubes  

作　　者：Yan-Sha Gao Li-Ping Wu Kai-Xin Zhang Jing-Kun Xu Li-Min Lu Xiao-Fei Zhu Yao Wu 

机构地区：[1]Jiangxi Key Labrotory of Organic Chemistry,Jiangxi Science and Technology Normal University [2]College of Science,Jiangxi Agricultural University

出　　处：《Chinese Chemical Letters》2015年第5期613-618,共6页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(No.51302117);the Natural Science Foundation of Jiangxi Province(Nos.20122BAB216011 and 20122BAB213007);Jiangxi Provincial Department of Education(No.GJJ13258);Postdoctoral Science Foundation of China(No.2014M551857);the Science and Technology Landing Plan of Universities in Jiangxi province (No.KJLD12081) for their financial support of this work

摘　　要：A simple and sensitive electroanalytical method for determination of shikonin, a widely used antitumoral agent, using β-cyclodextrin-functionalized multiwalled carbon nanotubes composite modified glassy carbon electrodes （MWCNTs/β-CD/GCE） was presented. CDs are water-soluble and environmentally friendly and can improve the dispersibility of MWCNTs/βCD functional materials, which was confirmed by SEM. The electrochemical behaviors of shikonin on different electrodes were investigated by cyclic voltammetry （CV） and differential pulse voltammograms （DPVs）. The results demonstrated that the redox peak currents of shikonin obtained at MWCNTs/fl-CD/GCE were much higher than those at the βCD/GCE and MWCNTs/GCE, which can be attributed to the combination of the excellent electrocatalytic properties of MWCNTs and the molecular recognition ability of βCD. At MWCNTs/ βCD/GCE, the response current exhibits a linear range from 5.0 nmol/L to 10.0 μmol/L with a detection limit of 1.0nmol/L （S/N=3）. As a practical application, the proposed method was applied to quantitatively determine shikoninin urine samples with satisfying results.A simple and sensitive electroanalytical method for determination of shikonin, a widely used antitumoral agent, using β-cyclodextrin-functionalized multiwalled carbon nanotubes composite modified glassy carbon electrodes （MWCNTs/β-CD/GCE） was presented. CDs are water-soluble and environmentally friendly and can improve the dispersibility of MWCNTs/βCD functional materials, which was confirmed by SEM. The electrochemical behaviors of shikonin on different electrodes were investigated by cyclic voltammetry （CV） and differential pulse voltammograms （DPVs）. The results demonstrated that the redox peak currents of shikonin obtained at MWCNTs/fl-CD/GCE were much higher than those at the βCD/GCE and MWCNTs/GCE, which can be attributed to the combination of the excellent electrocatalytic properties of MWCNTs and the molecular recognition ability of βCD. At MWCNTs/ βCD/GCE, the response current exhibits a linear range from 5.0 nmol/L to 10.0 μmol/L with a detection limit of 1.0nmol/L （S/N=3）. As a practical application, the proposed method was applied to quantitatively determine shikoninin urine samples with satisfying results.

关 键 词：Shikonin β-Cyclodextrin Multiwalied carbon nanotubes Modified electrode Electrochemical detection 

分 类 号：O657.1[理学—分析化学] O613.71[理学—化学]