机构地区:[1]首都医科大学附属北京同仁医院内分泌科,100730 [2]首都医科大学附属北京地坛医院病案统计室 [3]中央民族大学社区卫生服务中心 [4]首都医科大学附属第六医院月坛社区卫生服务中心 [5]北京西城区新街口社区卫生服务中心 [6]北京市朝阳区劲松社区卫生服务中心 [7]北京朝阳区东风社区卫生服务中心 [8]北京航天总医院东高地社区卫生服务中心 [9]北京市朝阳区崔各庄社区卫生服务中心
出 处:《中华全科医师杂志》2015年第6期422-426,共5页Chinese Journal of General Practitioners
基 金:首都卫生发展科研专项基金(2011-2005-01)
摘 要:目的探讨糖尿病前期合并高血压患者社区纵向管理后血压、血糖、血脂等控制效果。方法2008年7月至2011年7月对北京社区糖尿病研究中纳入的7个社区的糖尿病前期合并高血压患者共283例进行纵向随访管理3年,分析管理前后患者的血压、血糖、血脂等临床指标,降压药物应用情况及血压等各指标的达标情况。结果管理后患者脱落39例,资料完整244例。与管理前比较,244例患者管理3年后收缩压[(126±9)比(130±14)mmHg,1mmHg=0.133kPa]、舒张压[(75±7)比(77±9)mmHg]、空腹血糖[(5.7±1.0)比(6.0±0.8)mmol/L]、餐后血糖[(7.8±1.8)比(8.2±2.3)mmol/L]、尿酸I.(313±77)比(329±88)μmol/L]、LDL—C[(2.9±0.8)比(3.1±0.9)mmol/L]水平均有显著下降(t值分别为4.535、4.699、4.383、3.363、3.548、2.016,P〈0.01或〈0.05)。降压药物应用上,与管理前比较,管理3年后应用血管紧张素受体Ⅱ拮抗剂(ARB)比例增加(19%比13%,Х^2=4.238,P〈0.05);管理前后钙离子拮抗剂(CCB)都是应用最多的降压药(50%比54%,x。=2.534,P〉0.05);因部分服用1种降压药患者生活方式管理后血压达标停药,未服降压药患者比例从16%升高至22%。与管理前比较,管理3年后患者血压达标率明显增加(36%比25%,Х^2=7.043,P〈0.01),LDL—C达标率无明显改变(32%比29%,Х^2=0.616,P〉0.05),血糖、血压和血脂联合达标率明显增加(12%比5%,Х^2=8.441,P〈0.01)。结论糖尿病前期合并高血压患者经过规范的社区管理,患者降压药物的应用更加规范,其血压达标率以及血糖、血压、血脂联合达标率均有增加,但仍然比较低;社区对糖尿病前期患者不仅应重视血糖控制,同时也应对血压、血脂等大血管病变的危险因素进行综合管理�Objective To evaluate the effectiveness of longitudinal community management of prediabetic patients with hypertension. Methods Two hundred and eighty three pre-diabetic patients with hypertension were recruited in Beijing Community Diabetes Study from seven communities of Beijing, and the patients received longitudinal community management from July 2008 to July 2011. The blood pressure, blood glucose, blood lipids were measured; and the antihypertensive medication, blood pressure control and other indicators were examined before and after management. Results During the 3-year period, 39 cases dropped off and 244 patients completed the study. Compared with the baseline levels, systolic blood pressure [ (126 ±9) vs. (130 ±14) mmHg, 1 mmHg =0. 133 kPa], diastolic blood pressure [ (75 ±7) vs. (77 ± 9) mmHg], fasting glucose [ (5.7 ± 1.0) vs. (6.0 ± 0. 8) mmol/L], postprandial glucose [ (7.8 ± 1.8) vs. (8.2±2.3) mmol/L], uric acid [(313±77) vs. (329±88) μmol/L], LDL-C [(2.9+0.8) vs. (3. 1 ±0. 9) mmol/L] were significantly decreased (t = 4. 535, 4. 699, 4. 383, 3. 363, 3. 548, 2. 016, P 〈 0.01 or 〈 0.05 ) in 244 patients. After 3-year management, the medication of angiotensin ]] receptor antagonist (ARB) was increased ( 19% vs. 13%, X2 = 4. 238, P 〈 0. 05) ; while the proportion of calcium channel blockers (CCB) remained the highest medication (50% vs. 54% , Х^2 = 2. 534, P 〉 0. 05 ) after the management. The proportion of non-drug treatment patients rose from 16% to 22%, because of medication withdrawing after effective lifestyle management. The blood pressure control rate was significantly increased (36% vs. 25%, Х^2 =7.043, P 〈0. 01) after 3-year management; however, the control rate of LDL-C had no significant changes (32% vs. 29% , Х^2 = 0. 616, P 〉 0. 05 ). The proportion of patients who reached all three goal of blood glucose, blood pressure and blood lipids increased significantly ( 12% vs. 5%, Х^2 =
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