北京市郊区1336例农村体检者高尿酸血症患病情况及与年龄、血压、血糖和血脂的关系分析  被引量:17

Prevalence of hyperuricemia in health check-up population of Beijing suburb

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作  者:朱立新 周美岑[2] 崔向丽 冯林波 赵雪峰[3] 何书励 李玉秀[2] 

机构地区:[1]北京市昌平区南口社区卫生服务中心,102200 [2]中国医学科学院北京协和医学院北京协和医院内分泌科卫生部内分泌重点实验室 [3]北京市昌平区南口铁路医院 [4]中国医学科学院营养科

出  处:《中华全科医师杂志》2015年第6期432-436,共5页Chinese Journal of General Practitioners

摘  要:目的了解北京市昌平区南口镇农村人群高尿酸血症患病特点及其与血压、血糖和血脂等代谢异常的关系。方法2014年7月1日至8月30日该地区18岁以上常住农村户籍居民体检者1336例,比较不同年龄段者高尿酸血症的检出率。根据体检者年龄分为中青年组(20-59岁,686例)和老年组(60~96岁,650例),根据血尿酸水平从低到高分A、B、C、D4个组,每组334例,比较不同血尿酸水平者血压、血糖、血脂水平,分析高尿酸血症患者合并其他代谢异常的比例。结果①中青年组高尿酸血症检出率20.41%(140/686),显著性高于老年组的13.85%(90/650)(Х^2=10.08,P=0.001),老年组收缩压、空腹血糖、TC、LDL—C水平显著高于中青年组[收缩压:(126.8±15.7)与(116.7±12.0)mmHg(1mmHg=0.133kPa),t=2.76,P=0.008;空腹血糖:(7.40±4.10)与(6.11±2.03)mmo[/L,t=2.12,P:0.036;TC:(5.52±1.10)与(5.23±1.00)mmol,/L,t=2.04,P=0.045;LDL-C:(3.5±0.7)与(2.4±0.9)mmol/L,t=2.21,P=0.029];②不同血尿酸水平的4组问比较:D组BMI、空腹血糖显著高于A、B、C组[A、B、c、D组的BMI:(24.19±3.37)、(25.49±3.42)、(25.61±3.49)和(26.44±3.88)kg/m^2,t=2.78,P:0.008;空腹血糖:(6.34±1.34)、(6.09±1.51)、(6.40±1.98)和(8.19±1.52)mmol/L,t=2.80,P=0.007],c、D组的TG水平显著高于A、B两组[A、B、C、D组:(1.37±0.76)、(1.70±O.84)、(1.92±0.44)和(1.85±0.90)mmoL/L,t=2.1,P=0.035];③高尿酸血症患者不合并其他代谢异常者仅占9.57%(22/230),合并1种代谢异常者占20.87%(48/230),合并2种以上代谢异常者占69.57%(160/230)。结论在农村人群尤其中青年人群中加强对高尿酸的筛查,及早�Objective To investigate the prevalence of hyperuricemia in health check-up population of Beijing suburb. Methods Total 1 336 rural residents in Nankou Township of Beijing received health check-up from July to Aug 2014, including 686 subjects aged 20 -59 years (young/middle-aged group) and 650 subjects aged 60-96 years (elderly group). The blood pressure and body mass index (BMI) were measured; serum uric acid (SUA), fasting blood glucose (FBG) and blood lipids (TG, TC, HDL-C, LDL-C) were determined. The SUA levels 〉 420 p, rnol/L for male and 〉 360 μmoL/L for female were defined as hyperuricemia. Results The four quartiles of SUA levels were 27. 00 -254. 59 μ mol/L ( Q1 ), 254. 60-302. 35 wmol/L (Q2), 302. 36-359.78 p, mol/L(Q3)and 359.79-702.0 μmol/L (Q4). The prevalence of hyperurieemia was significantly higher in young/middle-aged group than that in elderly group [ 20.41% ( 140/686 ) vs. 13.85 % ( 90/650 ), X^2 = 10. 08, P = 0. 001 5 ], the systolic blood pressure [SBP, (126.8 ±15.7) vs. ( 116.7±12.0)mmHg(1 mmHg=0.133 kPa),t=2.76,P=0.008], FBG [(7.40±4.10) vs. (6.11 ± 2. 03 ) mmoL/L, t=2.12, P=0.036], TC [ (5. 52 ±1.10) vs. (5.23± 1.00) mmol/L,t =2.04,P =0. 045], LDL-C [ (3.5 ±0. 7) vs. (2.4 ±0. 9) mmol/L,t =2. 21 ,P =0. 029] in young/middle-aged group were significantly higher than those in elderly group. BMI, FBG were signifieantly higher in Q4 than those in other quartiles [ BMI: ( 26.44 ± 3.88 ) vs. ( 24. 19 ± 3.37 ), (25.49±3.42) and (25.61 ±3.49)kg/m2,t =2.78, P=0.008;FBG:(8.19±1.52) vs. (6.34±1.34), (6. 09 ± 1.51 ) and (6. 40 ± 1.98) mmol/L,t = 2. 80, P = 0. 007 ]. The triglyeeride (TG) levels in group Q3 and Q4 [ ( 1.85 ±0. 90) and ( 1.92 ±0.44) mmoL/L] were higher than those in Q1 and Q2 [ ( 1.37 ± 0. 76) and ( 1.70 ± 0. 84) retool/L, t = 2. 1, P = 0. 035 ]. Only 9.57% subjects (22/230)with hyperuricemia was not combined with metabo

关 键 词:高尿酸血症 肥胖症 代谢疾病 横断面研究 

分 类 号:R589.7[医药卫生—内分泌]

 

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