脑脊液相关指标联合检测在颅内感染诊断中的应用  

Clinical value of combined detection of cerebrospinal fluid-related indicators in diagnosis of intracranial infections

作　　者：温昌明[1] 王新凯 张保朝[1] 

机构地区：[1]南阳市中心医院神经内科 [2]解放军71669部队医院内科

出　　处：《中华医院感染学杂志》2015年第12期2728-2730,共3页Chinese Journal of Nosocomiology

基　　金：河南省自然科学基金资助项目(0511041900)

摘　　要：目的观察脑脊液中乳酸脱氢酶(LDH)、腺苷脱氨酶(ADA)、免疫球蛋白(Ig)及β-微球蛋白(β-MG)的改变在颅内感染诊断中的临床价值,有利于及时判断脑组织损害程度,以判断预后。方法对22例结核性脑膜炎组、34例化脓性脑膜炎组、28例病毒性脑膜炎组患者脑脊液中的LDH、ADA、Ig、β-MG的含量进行检测,同时选择同期未发生感染的24例患者作为对照组予以比较。结果 LDH水平化脓性脑膜炎组与结核性脑膜炎组比较,差异有统计学意义(P<0.05),化脓性脑膜炎组与病毒性脑膜炎组比较,差异有统计学意义(P<0.05),结核性脑膜炎组与病毒性脑膜炎组比较,差异有统计学意义(P<0.05),3组与对照组相比,差异有统计学意义(P<0.05);ADA水平化脓性脑膜炎组与结核性脑膜炎组比较,差异有统计学意义(P<0.05),化脓性脑膜炎组与病毒性脑膜炎组比较,差异有统计学意义(P<0.05),结核性脑膜炎组与病毒性脑膜炎组比较,差异有统计学意义(P<0.05),3组与对照组相比,差异有统计学意义(P<0.05);在IgA、IgG、IgM水平化脓性脑膜炎组与结核性脑膜炎组比较,差异有统计学意义(P<0.05),3组与对照组相比,差异有统计学意义(P<0.05)。结论脑脊液中LDH、ADA、Ig、β-MG的检测有助于3种常见脑膜炎的诊断,具有较高的临床价值。OBJECTIVE To observe the clinical value of the change of cerebrospinal fluid‐related indicators in diag‐nosis of intracranial infections ,including lactate dehydrogenase （LDH） ,adenosine deaminase （ADA） ,immuno‐globulin （Ig） ,andβ2‐microglobulin （β‐MG） ,so as to determine the extent of brain tissue damage as well as the prognosis .METHODS A total of 22 patients with tuberculous meningitis ,34 patients with purulent meningitis , and 28 patients with viral meningitis were enrolled in the study ,then the contents of LDH ,ADA ,Ig ,andβ‐MG in the cerebrospinal fluids of the participants were determined ,meanwhile ,24 patients without infections were re‐cruited as controls .RESULTS There was significant difference in the level of LDH between the purulent meningitis group and the tuberculous meningitis group （P〈 0 .05） ,there was significant difference between the purulent meningitis group and the viral meningitis group （P〈0 .05） ,there was significant difference between the tubercu‐lous meningitis group and the viral meningitis （P〈0 .05） ,and there was significant difference between the three groups and the control group （P〈0 .05） .There was significant difference in the ADA level between the purulent meningitis group and the tuberculous meningitis group （P〈0 .05） ,There was significant difference between the purulent meningitis group and the viral meningitis group （P〈0 .05） ,there was significant difference between the tuberculosis meningitis group and the viral meningitis group （P〈 0 .05） ,and there was statistically significant difference between the three groups and the control group （P〈0 .05） .There was significant difference in the level of IgA ,IgG ,or IgM between the purulent meningitis group and the tuberculous meningitis group （P〈0 .05） ,and there was significant difference between the three groups and the control group （P〈0 .05） .CONCLUSION The de‐tection of LDH ,ADA ,Ig ,and β‐MG is conducive to the diagnosis

关 键 词：脑脊液 免疫球蛋白 腺苷脱氨酶 乳酸脱氢酶 颅内感染 

分 类 号：R446[医药卫生—诊断学]