制霉菌素与氟康唑外用对口腔真菌感染治疗的效果分析  

Efficacy analysis of external application of nystatin and fluconazole treatment of oral fungal infection

作　　者：黄菊[1] 赵蔚萍[1] 雷先会 

机构地区：[1]遂宁市中心医院口腔科,四川遂宁629000

出　　处：《中华医院感染学杂志》2015年第12期2758-2759,2771,共3页Chinese Journal of Nosocomiology

基　　金：四川省卫生厅科研基金资助项目(110764)

摘　　要：目的探讨制霉菌素与氟康唑外用两种治疗方案对于口腔真菌感染的临床治疗疗效,以指导临床更加规范化的治疗。方法将2011年8月-2013年8月间质性肺炎并发口腔真菌感染的64例患者随机分为制霉菌素组及氟康唑组,每组各32例,制霉菌素组给予制霉菌素药膏治疗,而氟康唑组给予氟康唑外用治疗,治疗结束后判断两组患者临床治疗疗效。结果两组患者感染真菌类别比较,差异无统计学意义;患者治疗后总有效率制霉菌素组为93.8%、氟康唑组为68.8%,制霉菌素组患者治疗总有效率明显高于氟康唑组,差异有统计学意义(P<0.05)。结论制霉菌素治疗间质性的肺炎所致口腔真菌感染患者的临床疗效,明显优于氟康唑外用的治疗有效率,同时治疗方法简单、安全。OBJECTIVE To investigate clinical efficacy of nystatin vs .fluconazole for the treatment of oral fungal infection ,so as to guide more standardized clinical treatment . METHODS The 64 patients with interstitial pneumonia complicated by oral fungal infection during Aug .2011 to Aug .2013 were divided into the nystatin group and the fluconazole group with 32 patients in each group .The nystatin group was given nystatin ointment and the fluconazole group was given external fluconazole .The clinical efficacy was determined according to the clinical condition of the two groups of patients .RESULTS There was no significant difference in types of fungi between the two groups .The total effective rate was 93 .8% in the nystatin group and 68 .8% in the fluconazole group ,indicating the total efficiency in the nystatin group was significantly higher than in the fluconazole group （P〈0 .05） .CONCLUSION The clinical efficacy of nystatin for the treatment of oral fungal infection caused by interstitial pneumonia was significantly superior to that of fluconazole and the treatment was simple ,safe and worthy of clinical application .

关 键 词：制霉菌素 氟康唑 口腔真菌感染 

分 类 号：R978.1[医药卫生—药品]