Foxa2调控支气管哮喘气道黏液高分泌研究进展  

Research progress of Foxa2 regulates asthmatic airway mucus hypersecretion

作　　者：袁波[1] 梁娅莎[1] 罗凤鸣[1] 

机构地区：[1]四川大学华西医院全科医学科,成都610041

出　　处：《国际呼吸杂志》2015年第11期857-859,共3页International Journal of Respiration

摘　　要：支气管哮喘（简称哮喘）是一种由多种细胞及细胞组分参与的慢性气道炎症性疾病，以Th2型气道炎性反应、气道高反应性、气道重塑为其主要特征。叉头状转录因子2（the fork head boxtranscription factor-2, Foxa2）基因定位于染色体20p11．21，长度是2242bp，高表达于气道上皮细胞和肺泡Ⅱ型上皮细胞中。在肺发育过程中，Foxa2参与Th2型气道炎症、黏液生成以及杯状细胞化生调控。本文从Foxa2与哮喘气道黏液分泌、杯状细胞化生研究进展作一综述。Bronchial asthma （asthma） is a chronic airway inflammatory disease involved by many cells and cellular components, whose main features are Th2-dominated airway inflammatory reaction, airway hyperresponsiveness and airway remodeling. The fork head box transcription factor-2 （Foxa2） is located on chromosome 20pll. 21 ,with the length of 2 242 bp,is highly expressed in respiratory epithelial cells and alveolar type Ⅱ epithelial cells. In the process of lung development, Foxa2 regulates Th2 dominated airway inflammatory reaction, mucus formation and goblet cell metaplasia. This review will summarize the role of Foxa2 in asthmatic airway mucus secretion and goblet cell metaplasia.

关 键 词：哮喘 叉头状转录因子2 气道黏液分泌 杯状细胞化生 

分 类 号：R978.15[医药卫生—药品]