低共熔溶剂中β-吲哚衍生物的绿色合成  

Green Synthesis of β-Indole Derivatives in Deep Eutectic Solvent

作　　者：唐利平[1] 赵仕林[2] 罗峰[1] 陶凤[1] 

机构地区：[1]四川化工职业技术学院,四川泸州646005 [2]四川师范大学化学与材料科学学院,四川成都610068

出　　处：《精细化工》2015年第6期704-708,共5页Fine Chemicals

基　　金：四川省教育厅科研项目(142A0352)资助~~

摘　　要：在低共熔溶剂氯化胆碱/尿素中,芳香醛、吲哚和丙二腈三组分通过＂一锅法＂反应合成了10个2-[（3-吲哚基）-芳甲基]丙二腈衍生物（β-吲哚衍生物）,反应条件温和,产率达66%-94%。此外,还讨论了反应速度与取代基的关系,探讨了氯化胆碱/尿素的催化机理。催化剂回收利用5次仍然保持较高的催化活性,并运用^1HNMR、^13CNMR技术手段确定了产物的结构。Ten kinds of 2-[（ indol-3-yl）-arylmethyl]-malononitrile derivatives（ β-indole derivatives）were synthesized through one-pot three-component reactions of indole with aromatic aldehydes and malononitrile in the presence of the deep eutectic solvent（ DES） choline chloride / urea. The yields ranged between 66% ~ 94% under mild conditions. Furthermore,the relationship between reaction speed and substituent groups was described,and the catalytic mechanism for the reaction catalyzed by choline chloride / urea was proposed. The catalyst could be conveniently recovered five times without significant loss of its efficacy. All the compounds synthesized were confirmed by1 HNMR and13CNMR analysis.

关 键 词：低共熔溶剂 氯化胆碱/尿素 三组分反应 绿色合成 精细化工中间体 

分 类 号：TQ463[化学工程—制药化工]