介入联合冠脉注射替罗非班治疗急性心肌梗死的疗效观察  

Efficacy of intervention combined with intracoronary tirofiban on acute myocardial infarction

作　　者：陶林[1] 

机构地区：[1]广西壮族自治区柳州市人民医院心血管内科,545006

出　　处：《中国实用医刊》2015年第12期8-9,共2页Chinese Journal of Practical Medicine

摘　　要：目的探讨在经皮行冠状动脉介入（PCI）治疗时，联合冠脉内注射替罗非班对急性心肌梗死患者疗效和安全性的影响。方法将柳州市人民医院收治的150例行PCI治疗的急性心肌梗死患者随机分为给予单纯行PCI治疗的对照组，和在行PCI同时联合冠脉内注射替罗非班治疗的实验组，每组75例，然后将对照组患者与实验组患者治疗前后的左室射血分数、TIMI血流情况以及安全性进行比较、分析。结果实验组患者在术后的平均左室射血分数明显高于对照组患者，术后实验组患者的3级例数所占的比例为97．33％，明显高于对照组患者；实验组患者术后的出血率为10．66％，心血管事件发生率为4％，均明显低于对照组，差异均有统计学意义（P〈0．05）。结论介入联合冠状动脉内注射替罗非班能够显著增加急性心梗患者术后的冠脉灌注量，提高左室射血能力且安全性高，有重要的临床参考意义。Objective To evaluate the efficacy and safety of PCI treatment combined with intra- coronary injection of tirofiban on patients with acute myocardial infarction. Methods The study subjects were 150 patients with acute myocardial infarction during PCI treatment admitted to people＇ s hospital of Li- uzhou, the 150 cases were randomly divided into control group and experiment group, and the left ventricle ejection fraction, TIMI blood flow and safety were compared. Results The mean left ventricular ejection fraction of patients in experimental group after surgery was significantly higher than that of the control group, 3 cases of the experimental group proportion was 97.33% , it was significantly higher than that in control group, postoperative bleeding in patients of experimental group was 10. 66%, the cardiovascular e- vent rate was 4%, it was significantly lower than that in the control group. The differences were statistically significant （P 〈 0. 05）. Conclusions Interventional tirofiban can significantly increase coronary perfusion and improve left ventrieular ejection capability and safety after injection combined with coronary artery in patients with acute myocardial infarction, which has important clinical reference value.

关 键 词：急性心肌梗死 介入治疗 替罗非班 

分 类 号：R541.4[医药卫生—心血管疾病]