全固态普鲁卡因选择电极的制备与应用  

Preparation and Application of a Full-solid-state Procaine Selective Electrode

作　　者：徐成银[1] 郭智勇[1] 

机构地区：[1]科学技术学院、材料科学与化学工程学院、宁波大学,浙江宁波315211

出　　处：《中国医药工业杂志》2015年第6期628-630,657,共4页Chinese Journal of Pharmaceuticals

摘　　要：基于聚甲基丙烯酸甲酯一聚甲基丙烯酸二甲胺基乙酯（PMMA-PDMA）共聚膜的憎水性和聚邻甲苯胺（POT）的半导电性对普鲁卡因离子通量的有效抑制，以普鲁卡因一四苯硼钠离子缔合物为电活性物质，构建了高灵敏度全固态普鲁卡因选择电极。在pH3．5～5．5溶液中，电极的线性范围为lxl0～lxl0mol／L，斜率为52．04mV／pc，最低检测限为7×10～mol／L。该法选择性、精密度和准确度良好，可用于药品及人血清中普鲁卡因的测定。A full-solid-state procaine selective electrode with high sensitivity was prepared with the ion- pair of procaine-sodium tetraphenylborate as the electroactive substance, based on the hydrophobicity of poly （methyl methacrylate）-poly （dimethylaminoethyl methacrylate） （PMMA-PDMA） copolymer film and the semi-conduction of poly （o-toluidine） （POT）, which could inhibit ion flux of procaine effectively. The electrode showed a linear Nemst response in the range of 1 × 10^-7 - 1 × 10^-3 mol/L in pH 3.5 - 5.5, with a slope of 52.04 mV/pc. The low limit of detection was 7× 10^-8 mol/L. With good selectivity, precision and accuracy, this electrode was practicable for the analysis of procaine in pharmaceutical preparations and human serum.

关 键 词：普鲁卡因 全固态选择电极 共聚膜 聚邻甲苯胺 测定 

分 类 号：O657.15[理学—分析化学] TQ460.72[理学—化学]