Triton X-100六角液晶相中制备镁铝层状双金属氢氧化物纳米片及其药物载体应用  

Preparation of Mg_2Al Layered Double Hydroxide Nanosheets from Triton X-100 Hexagonal Lyotropic Liquid Crystal and Their Application as Drug Carriers

作　　者：赵继宽[1] 谢艳芳[1] 徐洁[1] 侯万国[2] 

机构地区：[1]青岛科技大学化学与分子工程学院,生态化工国家重点实验室培育基地,山东青岛266042 [2]山东大学胶体与界面化学教育部重点实验室,济南250100

出　　处：《物理化学学报》2015年第6期1199-1206,共8页Acta Physico-Chimica Sinica

基　　金：国家自然科学基金(20903059,21173135,21403121);山东省自然科学基金(ZR2009BM043,ZR2013BQ013)资助项目~~

摘　　要：以Triton X-100六角相溶致液晶作微反应器,采用共沉淀法制备了镁铝层状双金属氢氧化物(LDHs)纳米薄片(L-LDHs).以双氯芬酸钠(DS)为药物模型分子,采用离子交换法制备了DS插层LDHs(DS/L-LDHs)纳米杂化物,在37.0°C、p H=7.2的缓冲溶液中,考察了纳米杂化物的药物释放性能,并与传统溶液共沉淀法制备的镁铝LDHs(S-LDHs)纳米片状颗粒进行了对比.采用粉末X射线衍射(XRD)、傅里叶变换红外(FT-IR)光谱、场发射扫描电镜(FE-SEM)、透射电镜(TEM)和N2吸附-脱附等技术对所制备的LDHs和DS/LDHs样品的晶体结构、比表面积、形貌特征等进行了表征.结果表明,L-LDHs比S-LDHs具有更低的片厚度,更高的比表面积和药物负载量,所形成的DS/L-LDHs纳米杂化物药物释放速率也明显低于DS/S-LSHs,即L-LDHs更适于作药物载体.DS/L-LDHs纳米杂化物的药物释放过程符合准二级动力学方程,受颗粒内部扩散过程控制.溶致液晶模板法可实现LDHs的形貌可控制备,为LDHs基功能材料的研发提供了新途径.A hexagonal lyotropic liquid crystal （LLC） was constructed with nonionic surfactant Triton X-100 and mixed magnesium chloride/aluminum chloride aqueous solutions. Layered double hydroxide （LDH） nanosheets （L-LDHs） were prepared using the LLC as a microreactor. A nanohybrid material of L-LDHs intercalated with a model anionic drug, diclofenac sodium （DS; DS/L-LDHs） was synthesized using an ion- exchange method. The drug-release profile of DS/L-LDH was investigated under moderate conditions, i.e., 37.0 ℃ and pH 7.2. The results were compared with those for common LDH flaky particles （S-LDHs） synthesized using a traditional solution coprecipitation method. The crystalline structures, specific surface areas, and morphologies of these LDHs and DS/LDHs nanohybrids were characterized using powder X-ray diffraction （XRD）, Fourier-transform infrared （FT-IR） spectroscopy, field-emission scanning electron microscopy （FE-SEM）, transmission electron microscopy （TEM）, and N2 adsorption-desorption. The results show that the L-LDH particles are less thick, and have larger specific surface areas and higher DS-Ioading capacities than the S-LDH particles. Drug release by the DS/L-LDH nanohybrid was clearly lower than that by the DS/S-LDH nanohybrid. This indicates that the L-LDH nanosheets are more suitable for use as drug carriers than the S-LDHs. Drug release by the DS/L-LDH nanohybrid can be described using a pesudo-second-order kinetic model, and drug diffusion through the LDH particles is the rate-limiting step. LLC can be used as a template for morphology- controlled synthesis of LDHs.

关 键 词：层状双金属氢氧化物 溶致液晶 TRITON X-100 纳米杂化物 药物释放 

分 类 号：TB383.1[一般工业技术—材料科学与工程] TQ460.1[化学工程—制药化工]