齐拉西酮联合小剂量氯氮平对男性难治性精神分裂症患者认知功能的影响  

The Influence of Ziprasidone Combined with Small- dose of Clozapine on Cognitive Function in Male Patients with Refractory Schizophrenia

作　　者：蒋志浩[1,2] 陶领钢 李启斌[2] 周云[2] 

机构地区：[1]桂林医学院 [2]桂林医学院精神病与心理卫生学教研室

出　　处：《中国健康心理学杂志》2015年第6期810-814,共5页China Journal of Health Psychology

摘　　要：目的:观察齐拉西酮联合小剂量氯氮平对男性难治性精神分裂症患者认知功能的影响及临床疗效、安全性研究。方法:将100例男性难治性精神分裂症患者随机分为两组各50例,治疗组给予齐拉西酮联合小剂量氯氮平治疗,对照组给予氯氮平治疗。两组均于治疗前后采用阳性与阴性症状量表(PANSS)、韦氏成人智力量表(WAIS-RC)、个人与社会功能量表(PSP)及不良反应发生量表评定认知功能影响及临床疗效与安全性。结果:两组患者在治疗12周后PANSS总分及各因子分均明显下降,且差异具有统计学意义(t=16.98,P<0.05);治疗后,治疗组WAIS-RC评分及PSP评分均显著提高,且两组差异具有统计学意义(t=4.76,2.54;P<0.05);治疗12周后,两组间临床疗效相当,且治疗期间,治疗组不良反应的发生率明显低于对照组,两组差异具有统计学意义(χ2=4.24,P<0.05)。结论:齐拉西酮联合小剂量氯氮平治疗男性难治性精神分裂症与单用氯氮平治疗临床疗效相当,但安全性高,且能更好地改善患者的认知功能。Objective： To compare the influence of ziprasidone combined with small- dose of clozapine on cognitive function,efficacy safety in male patients with refractory schizophrenia. Methods： A total of 100 male patients with refractory schizophrenia were randomly divided into two groups with each group of 50 cases. Treatment group received ziprasidone and small- dose of clozapine while control group received clozapine only. Before and after treatment,clinical efficacy and symptoms were evaluated by positive and negative symptoms rating scale（ PANSS） and cognitive function were assessed by Wechsler Adult Memory Scale（ WAIS- RC） and personal and social performance scale（ PSP） while adverse reactions were assessed by side effects scale. Results： Compared with control group,patients in treatment group the PANSS total scores and positive symptoms,negative symptoms,psychopathology scores were decreased significantly after treatment 12 weeks,there were statistically significant（ t = 16. 98,P〈0. 05）;After treatment,there were significant improvements in WAIS- RC and PSP scores between two groups（ t = 4. 76,2. 54; P〈0. 05）; After 12 weeks,the total effectiveness between 2 groups were not significantly different,and during treatment,the group of treatment was significantly lower than the group of control in scores of occurrence of adverse reactions（ χ2= 4. 24,P〈0. 05）. Conclusion： Ziprasidone combined with small- dose of clozapine has the same effect as clozapine in clinical effect in patients with refractory schizophrenia,but more safe,and it improves cognitive function more better.

关 键 词：精神分裂症 齐拉西酮 氯氮平 认知功能 

分 类 号：R395.4[哲学宗教—心理学]