2-Hydroxymalonitrile——A Useful Reagent for One-step Synthesis of α-Hydroxy Esters  

作　　者：YANG Jianxin YIN Yunxing HE Zhenmin MA Li LI Xin ZHANG Zhiliu LIN Xiaojuan MA Rujian 

机构地区：[1]Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, P. R. China," [2]WuXi PharmaTech Co.Ltd., Shanghai 200131, P.R.China

出　　处：《Chemical Research in Chinese Universities》2015年第3期321-324,共4页高等学校化学研究（英文版）

基　　金：the National Natural Science Foundation of China（No.51209024）.

摘　　要：α-Hydroxy carboxylic esters and their derivatives are key substructures in a variety of biologically active natural products and numerous pharmaceuticals[1-3].A variety of methods for the synthesis of α-hydroxyesters via homologation of aldehydes or ketones have been developed and frequently used in organic synthesis[4-14].These approaches are generally based on the following routes（Scheme 1）.α-Hydroxy carboxylic esters and their derivatives are key substructures in a variety of biologically active natural products and numerous pharmaceuticals[1-3].A variety of methods for the synthesis of α-hydroxyesters via homologation of aldehydes or ketones have been developed and frequently used in organic synthesis[4-14].These approaches are generally based on the following routes（Scheme 1）.

关 键 词：α-Hydroxy ester One-pot synthesis 2-Hydroxymalononitrile 

分 类 号：TQ655[化学工程—精细化工] TQ225.4