槲皮素包合物微孔渗透泵片制备工艺  

Preparation of micro-porosity osmotic pump tablets containing quercetin-inclusion complex

作　　者：吴先闯[1] 郝海军[2] 宋晓勇[1] 张永州[1] 刘瑜新[1] 张红芹 

机构地区：[1]河南大学淮河医院药学部,河南开封475000 [2]上海医药工业研究院,上海200437 [3]国家中药制药工程技术研究中心,上海201203

出　　处：《中成药》2015年第6期1205-1209,共5页Chinese Traditional Patent Medicine

基　　金：河南省科技发展计划项目(144300510019);开封市科技发展计划项目(1403024)

摘　　要：目的制备槲皮素环糊精包合物单层渗透泵片。方法以体外累积释放度作为评价指标,采用单因素考察确定最优处方。结果渗透泵片片芯处方中乳糖用量、Na Cl用量和PEO用量以及包衣膜处方中包衣增重和致孔剂PEG4000用量对释药行为有较大影响,优化后的槲皮素渗透泵片在12 h内呈现良好的零级释放(r=0.995 7),药物累积释放比较完全(>90%)。结论以环糊精包合物为中间体,可以制备成12 h内零级释药特征明显的单层渗透泵片。AIM To prepare monolithic osmotic pump tablets containing quercetin-inclusion complex. METHODS The cumulative percentage release was taken as the standard for evaluation for the in vitro drug re- lease profile, single factor tests were for the determination of the optimal formulation. RESULTS The composition of core tablet （ the amount of lactose, NaC1 and polyethylene oxide （PEO） ） and coating （ coating level and the a- mount of PEG 4000） affected significantly the drug release. More than 90% of quercetin was released from the op- timized osmotic pump tablets in 12 hrs, and the optimized formulation achieved the desired zero-order release pro- file （ r = 0. 995 7）. CONCLUSION Monolithic osmotic pump tablets containing quercetin-inclusion complex as intermediate can deliver drug continually for 12 hrs.

关 键 词：槲皮素 包合物 微孔渗透泵片 

分 类 号：R944[医药卫生—药剂学]