抗环瓜氨酸肽抗体联合类风湿因子诊断类风湿关节炎的临床意义  

The clinical value of anti-CCP antibodies and rheumatoid factor to rheumatoid arthritis

作　　者：佘亚辉[1] 韩媛媛[1] 周光庭[1] 贾芳岩[1] 

机构地区：[1]安徽省亳州市人民医院检验科,236800

出　　处：《检验医学与临床》2015年第11期1580-1581,1584,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨类风湿关节炎(RA)血清标志物抗环瓜氨酸肽(CCP)抗体的临床价值,并分析其与类风湿因子(RF)的关联性。方法采用化学发光法检测CCP抗体,使用免疫散射比浊法检测RF,并对结果进行统计学分析。结果 113例RA患者抗CCP抗体对RA诊断的敏感性73.5%,阳性83例;84例非RA患者抗CCP抗体特异性97.6%,阳性2例。82例抗CCP抗体与RF检测结果相同(72.6%)。两者无相关性(P>0.05)。抗CCP抗体与RF联合检测的敏感性84.1%,特异性98.8%。结论抗CCP抗体与RF抗体联合检测可提高RA的特异性。Objective To analyze the value of anti-CCP antibodies to RA and relationshipof rheumatoid factor （RF）. Methods CCP antibodies were determined by chemiluminescence,rheumatoid factor was determined by im- mune nephelornetry,and the sensitivity, specificity and relationship were analyzed by SPSS20.0. Results Anti-CCP antibodies for RA diagnostic sensitivity was 73.5% （83/113） ,specificity was 97.6% （81/83）. There was no signifi- cant correlation between anti-CCP and RF antibodies （P〉 0.05 ）. Sensitivity of RF combined with anti CCP was 84.1% ,specificity was 98.8%. Conclusion Anti-CCP antibodies for RA diagnosis with high specificity and sensitivity; there was no correlation between anti CCP and RF. Combined detection can improve the diagnostic sensitivity and specificity of RA.

关 键 词：抗环瓜氨酸肽抗体 类风湿关节炎 类风湿因子 

分 类 号：R593.22[医药卫生—内科学]