盆腔器官脱垂的中医体质分析及与TGF-β1关系的临床研究  

The Analysis on the Traditional Chinese Medicine Constitutions of Patients with Pelvic Organ Prolapse and Correlation between TCM Constitutions with TGF- β1

作　　者：王小红[1,2] 李奕祺[1] 叶燕红[1] 李灿东[1] 

机构地区：[1]福建中医药大学,福建福州350122 [2]福建中医药大学附属人民医院,福建福州350004

出　　处：《中医药导报》2015年第13期29-31,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金青年基金项目(No.81102713);福建省卫生厅重点项目(No.wzzz0911)

摘　　要：目的:分析盆腔器官脱垂(POP)患者的中医体质特征及与TGF-β1关系。方法:采用中医体质量表,分析盆腔器官脱垂各体质类型的分布情况;用酶联免疫吸附测定法(ELISA)测定POP患者血清TGF-β1的含量,分析不同体质POP患者血清TGF-β1含量的差异及相关性。结果:POP患者兼夹体质占75.0%,单纯体质与兼夹体质构成比比较,差异有统计学意义(P<0.05)。POP患者中医体质出现的频率由高到低依次为:气虚质、阳虚质、气郁质、血瘀质、痰湿质、阴虚质、平和质、湿热质、特禀质。POP患者不同体质差异有统计学意义(P<0.05)。总体体质分布气虚质所占比例最大,占76.0%,阳虚质(32.0%)和气郁质(29.0%)次之。不同体质TGF-β1差异有统计学意义(P<0.05)。结论:盆腔器官脱垂患者中医体质主要为偏颇体质,以气虚质为主,其次为阳虚质、气郁质。盆腔器官脱垂不同体质患者TGF-β1表达有差异。Objection： To analyze the Traditional Chinese Medicine （TCM） constitutions of POP patients and explore correla- tion between TCM constitutions with TGF-β1. Methods： The scale for TCM constitution is adopted to analyze the distribution of different TCM constitutions of POP patients; the serum enzyme-linked immunosorbent assay （ELISA） is used to detect TGF-β1 content in the serum of POP patients, and to analyze how different TCM constitutions differentiates or correlates with TGF-β1 content in serum. Results： POP patients with more than one constitutions amount to 75% of the total, and the ratio between pa- tients with single constitution and those with several constitutions is statistically significant （P〈0.05）. The occurrence frequencies of different TCM constitutions rank from high to low as follows： Qi deficiency, Yang deficiency, Qi stagnation, Blood stasis, Phlegm dampness, Yin deficiency, Neutral constitution, Damp-heat, and Special constitution. The TCM constitutional difference in patients is statistically significant （P〈0.05）. Generally speaking, Qi deficiency, which takes up 76.0% in the distribution, is the largest part; it is followed by Yang deficiency （32.0%） and Qi stagnation （29.0%）. Different TGF-β1 due to different constitu- tions is statistically significant （P〈0.05）. Conclusion： The main parts of POP patients are those with biased constitutions, which include Qi-deficiency, Yang-deficiency, and Qi-stagnation. The TGF-β1 expressions of different POP patients are different.

关 键 词：盆腔器官脱垂 中医体质 气虚质 TGF-Β1 

分 类 号：R271.1[医药卫生—中医妇科学]