强化他汀对首次急性前壁心肌梗死患者直接PCI治疗后1年左心功能的影响  

The Infection of Intense Atorvastatin on Left Heart Function One Year after Acute Myocardial Infarction of the Anterior Wall and Direct PCI

作　　者：王丹[1] 王耿[2] 韩雅玲[2] 周薇薇[3] 马蕊[2] 

机构地区：[1]辽宁中医药大学研究生院,辽宁沈阳110032 [2]沈阳军区总医院心血管内科,辽宁沈阳110016 [3]沈阳军区总医院影像科,辽宁沈阳110016

出　　处：《创伤与急危重病医学》2015年第3期137-140,共4页Trauma and Critical Care Medicine

基　　金：辽宁省科学技术计划项目(2013225089);科技部课题(2012ZX09303016-002);研究者发起的研究基金(WS1803207)

摘　　要：目的探讨强化他汀对首次急性前壁心肌梗死患者直接冠状动脉介入术(PCI)治疗后1年左心功能的影响。方法选取2012年4月至2013年9月因首次急性前壁心肌梗死行PCI治疗的患者140例,其中同意行超声检查119例,随机分为2组:强化他汀组(A组)57例,常规他汀组(B组)62例。A组入院时给予阿托伐他汀80 mg,术后给予阿托伐他汀40 mg/d(晚间),直至术后30 d,此后20 mg/d(晚间);B组给予阿托伐他汀20 mg/d(晚间)。观察患者术后1年心脏超声结果,比较A组与B组患者左室舒张末内径(LVDD),左室射血分数(EF值)及短轴缩短率(FS值),明确强化他汀治疗对首次急性前壁心肌梗死患者直接PCI后1年左心功能的影响。结果 A组患者与B组患者入院时LVDD、EF值和FS值比较,差异无统计学意义;A组患者术后1年LVDD、EF值和FS值与入院时比较,差异有统计学意义(P<0.05);B组患者术后1年,LVDD与入院时比较,差异无统计学意义;EF值和FS值与入院时比较,差异有统计学意义(P<0.05);A组患者与B组患者术后1年LVDD、EF值和FS值相比较,差异有统计学意义(P<0.05)。结论强化他汀治疗可改善首次急性前壁心肌梗死患者直接PCI后1年左心功能。Objective To observe the influence of intense atorvastatin on left heart function one year after acute myocardial infarction of the anterior wall performed by the first time and direct PCI. Methods We selected 119 patients who had acute myocardial infarction of the anterior wall and underwent PCI at one year from April 2012 to September 2013. Cases were divided into two groups randomly with 57 patients in the intense atorvastatin group（ Group A）,and 62 patients in the conventional group（ Group B）. On admission,80 mg atorvastatin was delivered to group A,and 40 mg atorvastatin was delivered per night postoperatively until 30 days later. Then,20 mg atorvastatin was delivered per night. Group B was delivered 20 mg atorvastatin per night. We observed the influence of intense atorvastatin on left heart function after acute myocardial infarction of the anterior wall and direct PCI by comparing the LVDD,EF and FS of the two groups. Results On admission,LVDD,EF and FS had no statistically significant difference between the two groups. One year after the operation,LVDD,EF and FS were statistically significant（ P〈0. 05） comparing with admission in Group A,while LVDD had no statistically significant difference,and EF and FS were statistically significant（ P〈0. 05） when comparing with admission in Group B. One year after the operation,LVDD,EF and FS were statistically significant（ P〈0. 05） between the two groups. Conclusion Intensive-statin therapy can improve left heart function after acute anterior myocardial and direct PCI at 1 year.

关 键 词：强化他汀 首次急性前壁心肌梗死 直接冠状动脉介入术 左心功能 

分 类 号：R542.22[医药卫生—心血管疾病]