桑白皮各化学拆分组分化学成分研究  

Study on Chemical Constituents from Chemical Split Fractions of Mori Cortex

作　　者：冯卫生[1,2] 曹彦刚 李方[1,2] 张艳丽[1,2] 李春阁[1,2] 王小兰[1,2] 陈文静[1,2] 匡海学[3] 郑晓珂[1,2] 

机构地区：[1]河南中医学院药学院,郑州450046 [2]呼吸疾病诊疗与新药研发河南省协同创新中心,郑州450046 [3]黑龙江中医药大学药学院,哈尔滨150040

出　　处：《世界科学技术-中医药现代化》2015年第3期492-498,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部国家重点基础研究发展计划"973计划"项目(2013CB531802):宣泻利水中药的药性研究;负责人:郑晓珂

摘　　要：目的:研究桑白皮各化学拆分组分的化学成分。方法:利用Diaion HP-20、Toyopearl HW-40、Sephadex LH-20、MCI Gel CHP-20、硅胶柱等柱色谱技术以及制备液相技术,对桑白皮化学拆分组分进行分离纯化,并根据其理化性质和光谱数据鉴定化合物的结构。结果:从桑白皮各拆分组分中共分离并鉴定了23个化合物的结构,其中从30%乙醇组分中分离得到16个单体化合物,分别为:香草酸(1),3,4-二甲氧基苯酚(2),苯甲酸(3),丁香酸(4),kelampayoside A(5),对羟基苯丙酸(6),咖啡酸(7),氢化阿魏酸(8),6,7-二羟基香豆素(9),5,7-二羟基香豆素(10),桑色素-7-O-β-D-葡萄糖苷(11),liriodendrin(12),2,3-反式二氢桑色素(13),2,3-顺式二氢桑色素(14),2,3-反式二氢槲皮素(15),2,3-顺式二氢槲皮素(16);从50%乙醇组分中分离得到4个单体化合物,分别为:东莨菪亭(17),桑色素(18),山奈酚-7-O-β-D-葡萄糖苷(19),伞形花内酯(20);从80%乙醇组分中分离得到3个单体化合物,分别为:桑根酮R(21),cis-mulberroside A(22),白藜芦醇(23)。结论:化合物2,4-6,11,16,19为首次从该植物中分离得到。This article was aimed to study the chemical constituents from the chemical split fractions of Mori Cortex. The compounds were isolated with Diaion HP-20, Toyopearl HW-40, Sephadex LH-20, MCI Gel CHP-20, Silica gel column chromatography and preparative HPLC. Structures of compounds were identified by physieochemical properties and spectral analysis. The results showed that 23 compounds were obtained. And their structures were identified. The 16 compounds were obtained from the 30% ethanol fraction as vanillic acid （1）, 3,4-dimethoxyphenol （2）, benzoic acid （3）, syringic acid （4）, kelampayoside A （5）, p-hydroxyphenylpropionic acid （6）, caffeic acid （7）, hydroferulic acid （8）, 6,7-dihydroxycoumarin （9）, 5,7-dihydroxycoumarin （10）, morin-7-O-fl-D-glucopyranoside （11）, liriodendrin （12）, 2,3-trans-dihydromorin （13）, 2,3-cis-dihydromorin （14）, 2,3-trans-dihydroquercetin （15）, 2,3-cis-dihydroquercetin （16）. The 4 compounds were obtained from the 50% ethanol fraction as scopoletin （17）, morin （18）, kaempferol-7-O-fl-D-glucopyranoside （19）, umbelliferone （20）. The 3 compounds were obtained from the 80% ethanol fraction as sanggenon R （21）, cis-mulberroside A （22）, resveratrol （23）. It was concluded that compounds 2, 4-6, 11, 16, 19 were isolated from this plant for the first time.

关 键 词：桑科 桑白皮 化学拆分组分 化学成分 

分 类 号：R284.1[医药卫生—中药学]