石榴叶鞣质与菠萝叶酚对哺乳期小鼠生长的比较  

Comparison on Pomegranate Leaf Tennis and Ananas coumosus Leaf Phenols on Growth of Lactation Mice

作　　者：王欣佩[1] 邢东明[1] 姜敬非[1] 余煊[1] 严孝金[1] 雷帆[1] 杜力军[1] 

机构地区：[1]清华大学教育部蛋白质科学重点实验室生命科学学院医学院药物药理实验室,北京100084

出　　处：《世界科学技术-中医药现代化》2015年第3期526-530,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委面上项目(30801523):石榴叶总酚成分对脑缺血过程中PPARγ转录活性的影响及其脑保护作用研究;负责人:雷帆;清华大学实验室开放基金(LF20082377):调血脂药石榴叶鞣质质量标准关键技术研究;负责人:杜力军;科学技术部"重大新药创制"科技重大专项"十一五"计划课题(2011ZX09101-002-11):高低降脂胶囊治疗高脂血症Ⅲ期临床研究;负责人:邢东明;科学技术部"重大新药创制"科技重大专项"十二五"计划课题(2012ZX09103-201-041):糖脂代谢新药BLP的研究;负责人:邢东明

摘　　要：目的:观察石榴叶鞣质和菠萝叶酚通过母乳对哺乳期小鼠生长的影响。方法:给母鼠灌胃不同剂量的药物,观察新生小鼠的一般状况、体质量、尾长及脏器系数肝脏相关脂代谢调控因子的表达。结果:石榴叶鞣质和菠萝叶酚均可以通过母乳明显影响新生小鼠的生长发育,其中石榴叶鞣质的作用强于菠萝叶酚,同时可以明显下调新生小鼠肝脏的脂代谢相关酶的表达。结论:石榴叶鞣质和菠萝叶酚可以通过母乳影响新生小鼠的生长发育,其作用与影响肝脏脂代谢酶表达有关。哺乳期服用该药需引起注意。其临床意义尚有待于深入研究。This study was aimed to observe the effect of pomegranate leaf tennis and Ananas coumosus leaf phenols on the growth of lactating mice through breast milk. Intragastric administration of different doses of drug was given to maternal mice. The general condition of newborn mice, body weight, tail length and organ coefficient of liver-related factors regulating the expression of lipid metabolism were observed. The results showed that both pomegranate leaf tennis and A, coumosus leaf phenols can obviously affect the growth and development of newborn mice through breast milk. And the effect of pomegranate leaf tennis was stronger than A. coumosus leaf phenols. Meanwhile, it obviously downregulated the expression of liver-related lipid metabolism enzymes in newborn mice. It was concluded that pomegranate leaf tennis and A. coumosus leaf phenols can affect the growth and development of newborn mice through breast milk. Its effect was related to the influence of lipid metabolism enzyme in the liver. Attention should be paid on taking this medication during lactation. Its clinical significance still required in-depth study.

关 键 词：石榴叶 菠萝叶 小鼠 生长发育 哺乳期 

分 类 号：R285.5[医药卫生—中药学]