小续命汤有效成分组化学成分研究  

Chemical Constituents in Groups of Effective Components Extracted from Xiaoxuming Decoction

作　　者：张桥[1,2] 沈娟[1,2] 赵祎武[1,2] 王振中[1,2] 萧伟[1,2] 

机构地区：[1]江苏康缘药业股份有限公司,连云港222001 [2]中药制药过程新技术国家重点实验室,连云港222001

出　　处：《世界科学技术-中医药现代化》2015年第3期583-586,共4页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部重大新药创制项目(2011ZX09401-014):中药治疗心脑血管疾病有效成分组(群)的创新药物孵化基地;负责人:王振中

摘　　要：目的:研究小续命汤有效成分组的化学成分。方法:采用动态轴向压缩柱色谱对小续命汤有效成分组进行分离,通过光谱分析确定化合物的结构。结果:从小续命汤有效成分组中分离得到12个化合物,分别鉴定为正二十八烷酸、正十六烷醇、千层纸素A、汉黄芩素、黄芩素、粉防己碱、防己诺林碱、汉黄芩苷、黄芩苷、芍药苷、苦杏仁苷、甘露醇。结论:所有化合物均为首次从该复方中分离得到。This article was aimed to study the chemical constituents in groups of effective components extracted from Xiaoxuming Decoction. Twelve compounds were isolated and purified by dynamic axial compression column chromatography. Their chemical structures were identified by spectral analysis. The results showed that twelve compounds were isolated and identified as octacosanoic acid（l）, cetanol（2）, oroxylin A（3）, wogonin（4）, baicalein（5）, tetrandrine（6）, fangchinoline（7）, wogonoside（g）, baicalin（9）, paeonii3orin（10）, amygdalin（11）, manntol（12）. It was concluded that all compounds were isolated from this compound prescription for the first time.

关 键 词：动态轴向压缩柱色谱 化学成分 有效成分组 小续命汤 

分 类 号：R284[医药卫生—中药学]