广东地产清热解毒药材药理研究及有关思路与方法探讨  

Discussion on Pharmacological Research, Relevant Ideas and Methods of Guangdong Native Heat-clearing and Toxin-removing Herbs

作　　者：高玉桥[1] 梅全喜[1] 曾聪彦[1] 彭伟文[1] 钟希文[1] 戴卫波[1] 范文昌[1] 胡莹[1] 李红念[1] 

机构地区：[1]广州中医药大学附属中山中医院,中山528400

出　　处：《世界科学技术-中医药现代化》2015年第3期655-663,共9页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：广东省中医药局基金资助项目(20131078):广东地产药材清热解毒药药效学与制剂开发研究;负责人:梅全喜;中山市科技基金重点资助项目(20132A002):广东地产清热解毒药的基础物质;药理作用及其制剂质量标准提高与制剂开发研究;负责人:;梅全喜

摘　　要：目的:通过整理广东地产清热解毒药的有关药理作用研究,探讨有关的思路与方法。方法:搜集广东地产清热解毒药和制剂药理研究的相关文献,并加以整理、归纳及分析。结果:广东地产清热解毒药大多有明显的抗病原微生物、抗细菌内毒素、抗炎、解热作用,还有一些有明显的抗蛇毒、镇痛等作用。在研究广东地产清热解毒药材药理作用的方法思路上,尽快澄清品种的混乱情况,坚持以整体动物实验为主,配合离体实验、计算机分子对接模拟,相互补充。结论:广东地产清热解毒药材的药理作用研究为其临床应用提供了有力支持;本文提出的方法和思路是阐释广东地产清热解毒药材药理作用的主要途径。This study was aimed to investigate the research on pharmacological effects, relevant ideas and methods of Guangdong native heat-clearing and toxin-removing herbs. Literatures on pharmacological effects of Guangdong native heat-clearing and toxin-removing herbs were collected, summarized and analyzed. The results showed that most Guangdong native heat-clearing and toxin-removing herbs had obvious effects of anti-microbial, anti-bacterial endotoxin, anti-inflammatory, and antipyretic effect. It also had obvious antivenomous and analgesia effect. Based on research ideas and methods of Guangdong native heat-clearing and toxin-removing herbs, we clarified the confusion species as soon as possible, and adhered to the whole animal experiments in combination with in vitro experiments and computer molecular docking simulations for the complementation of each other. It was concluded that the study on pharmacological effects of Guangdong native heat-clearing and toxin-removing herbs provided strong support in its clinical application. Ideas and methods provided in this article was the main way to explain pharmacological effects of Guangdong native heat-clearing and toxin-removing herbs.

关 键 词：广东地产清热解毒药 药理作用 研究方法 研究思路 

分 类 号：R285[医药卫生—中药学]