微波消解-ICP-MS法测定川芎和天麻药材中5种重金属元素  

Determination of Five Heavy Metals in Chuanxiong Rhizoma and Gastrodiae Rhizoma by ICP-MS

作　　者：谢达温[1] 廉源沛[1] 梁文琳 孙永成[1] 李艳静[1] 丁岗[1] 萧伟[1] 

机构地区：[1]江苏康缘药业股份有限公司中药制药过程新技术国家重点实验室,连云港222001 [2]中国药科大学中药学院,南京210009

出　　处：《世界科学技术-中医药现代化》2015年第3期740-743,共4页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部重大新药创制重大科技专项(2012ZX09201201-002):偏头痛治疗药物天舒胶囊大品种技术改造;项目负责人:萧伟

摘　　要：目的:使用电感耦合等离子体质谱仪(ICP-MS),建立川芎和天麻中Cu、As、Pb、Cd、Hg共5种重金属元素的测定方法。方法:样品经过微波消解处理后,采用外标法,用ICP-MS进行测定。结果:各元素线性关系良好(R2>0.999),最低检出限为0.003-0.134μg·L-1,回收率为80.04%-118.34%。结论:该方法准确、简便、快速、灵敏,适用于川芎和天麻药材中重金属的含量测定。This article is aimed to provide a method for the simultaneous analysis of five heavy metals, including Cu, As, Pb, Cd, and Hg, in Chuanxiong Rhizoma and Gastrodiae Rhizoma through ICP-MS. Five heavy metals were determined by an inductively coupled plasma-mass spectrometry method after microwave-assisted digestion. The linear correlation coefficients were all better than 0.999. The lowest limits of quantification for all target elements were 0.003-0.134 ug L-1, while the recovery values ranged from 80.04%-118.34%. This method was accurate, convenient, rapid, and highly sensitive, and can be applied to determine five heavy metals, including Cu, As, Pb, Cd, and Hg in Chuanxiong Rhizoma and Gastrodiae Rhizoma.

关 键 词：ICP-MS 微波消解 川芎 天麻 重金属 

分 类 号：R284.1[医药卫生—中药学]