金纳米棒:合成、修饰、自组装、SERS及生物医学应用  

Preparation,modification,self-assembly and surface enhanced Raman scattering of gold nanorods and its biomedical application

作　　者：杨玉东[1] 刘公召[1] 徐菁华[1] 杨林梅[1] 李冬至[1] 

机构地区：[1]沈阳工业大学理学院,沈阳110870

出　　处：《中国科学：化学》2015年第6期581-596,共16页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(50375102);沈阳工业大学博士后启动基金(521101302)资助

摘　　要：纳米颗粒作为信号感应单元在化学与生物传感应用中已引起广泛关注,这些功能和金属纳米结构与光相互作用时产生的表面等离子体共振密切相关.表面增强拉曼散射(SERS),是指吸附在粗糙的金属纳米结构表面的被分析物,在光照射下其拉曼光谱获得显著增强的异常表面光学现象,近年来.SERS技术已广泛用于物质检测和生物传感等研究,在生物医学领域表现出巨大的应用潜力并取得了令人瞩目的研究成果.本文阐述了金纳米棒的制备方法、表面修饰和共轭生物分子的方法.并从金纳米棒表面增强拉曼散射的角度系统阐述基于金纳米棒表面增强拉曼散射的1D,2D,3D自组装,并介绍了近期金纳米棒表面增强拉曼散射在生物医学检测与成像中最具有代表性的应用研究.Nanoparticle as a signal sensing unit in chemical and biological sensing applications has attracted wide attention. The features above are closely related with the surface plasmon resonance generated by the interactions between the light and metal nanostructures. Surface-enhanced Raman scattering （SERS） refers to an abnormal surface optical phenomenon Raman spectra of the analyte adsorbed on metal nanostructures can be significantly enhanced under laser irradiation. In recent years SERS has been widely used in the substance detection and biological sensing which has achieved significant development and shown great potential applications in the biomedical field. The progress of preparation methods, surface modification of gold nanorods, as well as conjugate method of biological molecules are reviewed in this paper. From the angle of surface enhanced Raman scattering （SERS）, the self-assemblies of 1D, 2D and 3D based on gold nanorods＇ SERS are systematically expounded. At last, the paper introduces the most representative of gold nanorods applied research on SERS in biomedical detection and imaging.

关 键 词：金纳米棒 表面增强拉曼散射 自组装 

分 类 号：TB383.1[一般工业技术—材料科学与工程] O657.37[理学—分析化学]