益生菌联合早期肠内营养治疗重症急性胰腺炎的疗效探讨  

Efficacy of probiotics combined with early enteral nutrition in patients with severe acute pancreatitis

作　　者：张俊烁[1] 周家德[1] 彭淮都[1] 蔡楚东[1] 方喜[1] 

机构地区：[1]汕头市中心医院外二科,广东汕头515031

出　　处：《中外医疗》2015年第6期76-77,80,共3页China & Foreign Medical Treatment

摘　　要：目的探讨益生菌联合早期肠内营养治疗重症急性胰腺炎的临床疗效。方法选取该院2012年5月—2014年9月收治的50例重症急性胰腺炎患者,随机分为两组,对照组和观察组各25例。两组患者均给予胃肠减压、抗感染等常规治疗,对照组在此基础上进行全胃肠胃营养治疗,观察组联合使用益生菌和早期肠内营养治疗,比较两组患者在感染率、腹痛消失时间、住院时间、住院费用、血浆白蛋白、C-反应蛋白(CRP)、血淀粉酶(AMS)、体重等方面的差异。结果观察组治疗后感染率为8%(2/25),显著低于对照组的16%(4/25),差异有统计学意义(P<0.05);观察组患者平均腹痛消失时间、住院时间、住院费用、体重均优于对照组(P<0.05);治疗2周后观察组白蛋白水平显著提高,CRP、淀粉酶含量明显降低,与对照组相比差异有统计学意义(P<0.05)。结论益生菌联合早期肠内营养治疗重症急性胰腺炎具有确切疗效,可显著均衡肠道菌群微生态,保护肠道黏膜屏障,降低感染率,加快疾病康复,值得在临床上推广应用。Objective To evaluate the clinical efficacy of probiotics combined with early enteral nutrition in the treatment of severe acute pancreatitis. Methods 50 cases of severe acute pancreatitis patients were randomly divided into two groups,the control group and observation group.All patients were treated with decompression, antibiotics and other conventional treatment.On the basis, the control group were given total parenteral nutrition therapy stomach, the observation group combined with probiotics and early en-teral nutrition therapy.Two groups were compared in infection, abdominal pain time, hospitalization time ,hospitalization expenses, serum albumin and C--reactive protein （CRP）, serum amylase （AMS） levels ,weight differences. Results After treatment, the infec-tion rate in observation group was 8% （2/25）, significantly lower than the 16% （4/25）in the control group（P 〈0.05）;The abdominal pain, hospitalization time, hospital costs and weight the observation group were better than the control group （ P 〈0.05）;2 weeks af-ter treatment, the observation group albumin levels were significantly increased amylase and CRP decreased significantly （P〈0.05）. Conclusion Probiotics combined with early enteral nutrition in patients with severe acute pancreatitis has a definite effect, can significantly balanced intestinal flora microflora, protect the intestinal mucosal barrier, reducing infection rates, accelerate recovery from disease, worthy of clinical application.

关 键 词：益生菌 早期肠内营养 重症急性胰腺炎 

分 类 号：R657.51[医药卫生—外科学]