左氧氟沙星注射剂在呼吸道感染中的应用疗效  

Efficacy of Levofloxacin Injection in the Treatment of Respiratory Tract Infection

作　　者：黄红 

机构地区：[1]江苏省苏州市吴江区第一人民医院,江苏苏州215200

出　　处：《中外医疗》2015年第7期10-11,共2页China & Foreign Medical Treatment

摘　　要：目的探讨左氧氟沙星注射液在呼吸道感染中的疗效。方法选取2013年8月—2014年4月该院收治的呼吸道感染病人110例,并按随机数字表法分为对照组和观察组,各55例。对照组给予低剂量左氧氟沙星治疗:200 mg/次,2次/d;观察组给予高剂量左氧氟沙星治疗,400 mg/次,1次/d。比较两组的治疗总有效率、临床症状消失时间、住院时间和不良反应。结果观察组的治疗总有效率为92.7%(51/55),明显高于对照组的78.2%(43/55)(χ2=4.681,P=0.031)。观察组的退热时间、咳嗽停止时间、流涕/鼻塞消失时间和住院时间均显著地低于对照组(t=6.633,P=0.000;t=5.933,P=0.000;t=8.228,P=0.000;t=3.982,P=0.000)。观察组的不良反应率为3.6%(2/55),明显低于对照组的16.4%(9/55)(χ2=4.949,P=0.026)。结论一次性给予呼吸道感染疾病患者400 mg左氧氟沙星能够显著地缓解呼吸道感染的各种临床症状,改善病情,促进病情康复。Objective To investigate the efficacy of Levofloxacin injection in the treatment of respiratory tract infection. Methods 110 cases with respiratory tract infection admitted in our hospital from August 2013 to April 2014 were selected and divided into control group and observation group with 55 cases in each in accordance with the random number table method. The control group were treated by a low dose of Levofloxacin, 200mg at a time, twice a day, while the observation group were treated by a high dose of Levofloxacin, 400 mg at a time, once a day. And the total effective rate, clinical symptoms disappearing time, hospitalization time and adverse reactions of the two groups were compared. Results The total effective rate of the observation group was 92.7%（51/55）, which was significantly higher than 78.2%（43/55） of the control group （χ^2=4.681, P=0.031）. The fever abatement time, cough disappearing time, runny/stuffy nose disappearing time and hospitalization time of the observation group were significantly less than those of the control group （t=6.633, P=0.000; t=5.933, P=0.000; t=8.228, P=0.000; t=3.982, P=0.000）. The incidence of adverse reactions of the observation group was 3.6%（2/55）, which was much lower than 16.4%（9/55） of the control group（χ^2=4.949, P=0.026）. Conclusion 400mg Levofloxacin given to the patients with respiratory tract infection at a time can significantly relieve the clinical symptoms of respiratory tract infection, improve the conditions and promote the recovery.

关 键 词：左氧氟沙星 低剂量 高剂量 呼吸道感染 

分 类 号：R56[医药卫生—呼吸系统]