创伤性颅脑损伤患者脑脊液H_2S变化及其意义  

Determination of H2S Levels in Cerebrospinal Fluid in Patients with Craniocerebral Trauma and Its Significance

作　　者：侯文娟[1] 叶同[1] 杨晓明[1] 冯杰[1] 冯贵龙[1] 

机构地区：[1]山西医科大学第一临床医学院急诊科,山西太原030001

出　　处：《中外医疗》2015年第11期7-9,共3页China & Foreign Medical Treatment

基　　金：国家重点科室建设专项基;北京协和医学基金一睿E(睿意)急诊医学科研专项基金

摘　　要：目的测定创伤性颅脑损伤患者脑脊液硫化氢的浓度,探讨该浓度与损伤程度的关系及其临床意义。方法选择颅脑外伤患者60例,根据GCS评分分为轻、中、重3组。分别留取创伤后12-24 h之内的脑脊液标本,采用分光光度法测定脑脊液中H_2S浓度。另取6例健康者作为对照组。结果 60例颅脑外伤患者脑脊液中H_2S浓度[(32.17±6.67)μmmol/L]明显高于对照组[(11.32±3.58)μmmol/L],差异有统计学意义(P<0.05),23例重伤组脑脊液H_2S浓度[(55.15±4.05)μmmol/L]明显高于中度组[(27.06±9.63)μmmol/L]、轻度组[(11.98±3.26)μmmol/L],差异有统计学意义(P<0.05),中度组浓度高轻度组,差异有统计学意义(P<0.05),轻度组与对照组比较差异无统计学意义(P>0.05)。结论颅脑外伤患者脑脊液H_2S浓度升高;损伤程度越重,H_2S浓度含量越高,可作为预测颅脑损伤严重程度的指标。Objective To assay the H2S level in cerebrospinal fluid （CSF） in patients with craniocerebral trauma and investigate the relation between H2S level and injury degree and the clinical significance.Methods In this study, 60 patients with craniocerebral trauma were enrolled and divided into three groups according to the GCS score, the mild injury group, moderate injury group and severe injury group. The CSF samples of the three groups were collected in 12~24 h after traumatic brain injury, and the H2S level in the CSF was assayed by spectrophotometry. And other 6 healthy people were selected as the control group. Results The analysis showed that the concentration of H2S level in the CSF of 60 cases in the craniocerebral trauma group was [（32.17±6.67）μmmol/L] ,much higher than [（11.32±3.58）μmmol/L] in the control group with statistically significant difference（P〈0.05）. The H2S level in the CSF of 23 cases in the severe injury group was [（55.15±4.05）μmmol/L], much higher than [（27.06±9.63）μmmol/L] of the moderate injury group and [（11.98±3.26）μmmol/L] of the moderate injury group with statistically significant difference（P〈0.05）. The concentration of H2S level in the CSF of the moderate injury group was higher than that in the mild injury group with statistically significant difference（P〈0.05）, but no statistically significant difference was found between the mild injury group and control group in concentration of H2S level in the CSF（P〉0.05）.Conclusion The level of H2S in CSF increases in patients with craniocerebral trauma. And the higher concentration of H2S is, the more severe the craniocerebral trauma will be, so it can be used as an index for predicting the severity of brain damage.

关 键 词：颅脑外伤 脑脊液 硫化氢 分光光度 

分 类 号：R4[医药卫生—临床医学]