铁过载人群外周血相关指标变化分析  

Aanalysis on Changes of Peripheral Blood Indicators in Iron Overload Population

作　　者：张冠军[1] 王燕[2] 任立晟[2] 孙晓岚[2] 郭郡[2] 贾茹[1] 吕建锋[1] 马爱国[1] 

机构地区：[1]青岛大学医学院营养研究所,山东青岛266021 [2]青岛大学附属医院,山东青岛266021

出　　处：《中国食物与营养》2015年第5期75-78,共4页Food and Nutrition in China

基　　金：国家自然科学基金(项目编号:81373000)

摘　　要：目的：探讨铁过载人群外周血相关指标的变化及血清铁蛋白（SF）和铁营乔、血常规指标之间的关系，为铁过载的诊断及分类提供科学依据。方法：随机抽取196名铁正常人群（男SF：15-200μg／L、女SF：15～150μg／L）和226名铁过载人群（男SF：〉200μg／L、女SF：〉150μg／L）。采用放射免疫法检测SF浓度，检测铁营养状况和血常规指标，分析血清铁蛋白和铁营养、血常规指标之间的相关性。结果：铁过载人群血清铁浓度22．93μmol／L和转铁蛋白饱和度36％显著高于铁正常组的17．83μmol／L和28％（P〈0．05），铁过载组人群不饱和铁结合力水平为40．69μmol／L和转铁蛋白浓度245．67mg／dL，显著低于正常组的46．97μmol／L和264．33mg／dL（P〈0．05），两组间总铁结合力水平的比较无显著差异（P〉0．05）；铁过载组红细胞计数平均为4．98×10^12／L和血红蛋白含量平均为155g/L，显著高于铁正常组的4．82×10^12／L和147g／L（P〈0．05），铁过载组红细胞压积44％和平均红细胞血红蛋白含量31．17pg，显著高于铁正常组人群的42％和30．61Pg（P〈0．05），两组之间白细胞计数和血小板计数的比较无显著差异（p〉0．05）。相关分析显示，血清铁蛋白与血清铁、转铁蛋白饱和度、红细胞计数、白细胞计数、血红蛋白、红细胞压积和平均红细胞血红蛋白含量呈显著正相关（P〈0．05），与不饱和铁结合力、转铁蛋白水平和血小板计数呈显著负相关（P〈0．05）。结论：中老年人群铁过载时，机体内血清铁、转铁蛋白饱和度、红细胞计数、血红蛋白、红细胞压积和平均红细胞血红蛋白含量均升高，不饱和铁结合力和转铁蛋白水平均降低；血清铁蛋白和血红蛋白呈显著正相关。因此，采用血常规检查和铁营养指标的联合检测来评价铁过载的程度，可为铁过载的早期发现、早[Objective] To explore the changes of indicators in peripheral blood of iron overload and the relationship between serum ferritin and indicators in peripheral blood. [[Method] Totally 196 iron normal people （male SF： 15 -200μg/L; female SF： 15 -150μg/L） and 226 i- ron overload people （male： SF 〉200μg/L; female： SF 〉 150μg/L） were randomly selected from SF concentration detected by radioimmunoas- say. Iron status and blood indicators were detected and the correlation between serum ferritin and iron nutrition and blood indicators were ana- lyzed. [Result] The serum iron concentration （22. 93μmol/L） and transferrin saturation （36%） in iron overload group was significantly higher than 17. 83μmol/L and 28% in iron normal group （P 〈0. 05）, the unsaturated iron binding capacity level （40. 69μmol/L） and transferrin con- centration （245.67mg/alL） in iron overload group was significantly lower than 46. 97μmol/L and 264. 33 mg/dL in the iron normal group （P 〈 O. 05）, while total iron binding capacity levels were no significant difference between the two groups （P 〉0. 05） ; the erythrocyte count （4. 98 × 10^12/L） and hemoglobin （155g/L） in iron overload group was significantly higher than 4. 82 × 10^12/L and 147g/L in iron normal group （P 〈 0.05）, the hematocrit （44%） and mean corpuscular hemoglobin （31.17pg） in iron overload group was significantly higher than 42% and 30. 61pg in iron normal group （P 〈0. 05）, there was no significant difference in comparison to the two groups on white blood cell count and platelet count （P 〉 0. 05 ） . There were a positively correlation between serum ferritin, serum iron, transferrin saturation, red blood cell count, white blood cell count, hemoglobin, hemoglobin, and mean corpuscular hemoglobin, and a negatively correlation between unsaturated iron binding capacity, transferrin concentration and platelet counts （P 〈 O. 05 ） . [Conclusion ] The serum iron, transferrin saturation, red bloo

关 键 词：铁过载 铁营养 血常规 血清铁蛋白 

分 类 号：R446.1[医药卫生—诊断学]