哮喘患儿血清Clara细胞分泌蛋白、白细胞介素-18、嗜酸粒细胞趋化蛋白检测的意义  

Clinical Significance of Clara Cell Secretary Protein,Interleukin-18,Eotaxin in Asthmatic Children

作　　者：吴书杭 袁晓霞[1] 张蔓莉[1] 

机构地区：[1]深圳市蛇口人民医院,广东深圳518067

出　　处：《儿科药学杂志》2015年第6期4-6,共3页Journal of Pediatric Pharmacy

摘　　要：目的:探讨哮喘儿童血清Clara细胞分泌蛋白(CCSP)、白细胞介素-18(IL-18)、嗜酸粒细胞趋化蛋白(Eotaxin)水平与哮喘的关系及其检测意义。方法:采用酶联免疫吸附法(ELISA)检测39例支气管哮喘患儿急性发作期血清CCSP、IL-18、Eotaxin的水平,选取同期健康儿童37例作为对照组。结果:哮喘组患儿血清CCSP浓度为(4.5±0.6)ng/m L,低于对照组的(12.4±2.6)ng/m L;哮喘组患儿血清IL-18浓度为(786.6±69.4)pg/m L,高于对照组的(96.3±11.9)pg/m L;哮喘组患儿血清Eotaxin浓度为(147.0±43.0)ng/m L,高于对照组的(84.0±32.0)ng/m L,两组比较差异均有统计学意义(P均<0.05)。结论:CCSP在哮喘患儿呼吸道炎症损伤、修复、呼吸道重塑过程中可能起保护作用;IL-18、Eotaxin因子参与了气道黏膜损伤的病理过程且与哮喘发作密切相关。Objective： To evaluate the expression and clinical significance of clara cell secretory protein （CCSP）, interleukin-18 （IL-18） and Eotaxin levels in children with asthma. Methods： Serum CCSP, IL-18 and Eotaxin levels in 39 children with acute asthmatic and 37 healthy children were assessed with enzyme-linked immunosorbent assay （ELISA）. Results： Serum concentration of CCSP in asthma group was （4.5±0. 6） ng/mL, lower than the control group （ 12. 4＋2. 6） ng/mL. Serum concentration of IL-18 in asthma group was （786. 6±69.4） pg/mL, higher than the control group （96. 3 ± 11.9 ） pg/mL. Serum concentration of Eotaxin in asthma group was （147.0±43.0） ng/mL, higher than the control group （ 84. 0±32. 0） ng/mL, the differences were statistically significant （ P〈0. 05 ）. Conclusion： CCSP may play a protective role in anti-inflammation in the airway. IL-18, Eotaxin factors involved in the pathogenesis of airway mucosa and are closely related to the onset of asthma.

关 键 词：哮喘 儿童 CLARA细胞分泌蛋白 白细胞介素-18 嗜酸粒细胞趋化蛋白 

分 类 号：R725.6[医药卫生—儿科]