川崎病患儿血清降钙素原、白细胞介素-6和D-D二聚体检测的临床意义  

Detection and Clinical Significance of Serum Procalcitonin,Interleukin-6 and D-D Dimer in Children with Kawasaki Disease

作　　者：邱红[1] 邱海燕[1] 张若松[1] 陈亚萍[1] 

机构地区：[1]宁波市妇女儿童医院,浙江宁波315000

出　　处：《儿科药学杂志》2015年第6期6-8,共3页Journal of Pediatric Pharmacy

摘　　要：目的:检测川崎病(KD)患儿治疗前后血清降钙素原(PCT)、白细胞介素-6(IL-6)、D-D二聚体水平的变化,探讨其临床意义。方法:选取2012年11月至2013年10月于我院住院的急性期KD患儿30例,根据心脏彩超结果分为冠状动脉病变(CAL)组和非冠状动脉病变(NCAL)组各15例,分别检测静脉注射丙种球蛋白(IVIG)治疗前后血清PCT、IL-6、D-D二聚体水平,并以同期健康体检儿童30例作为正常对照组。血清PCT检测采用电化学发光免疫分析法,IL-6测定采用酶联免疫吸附法,D-D二聚体测定采用免疫比浊法。结果:KD患儿IVIG治疗前PCT、IL-6、D-D二聚体水平均明显高于治疗后和对照组(P均<0.01),CAL组PCT、IL-6、D-D二聚体水平均高于NCAL组(P均<0.05)。结论:PCT、IL-6、D-D二聚体可作为KD早期诊断及预测病情的重要指标,其水平与冠状动脉损伤程度密切相关。Objective： To investigate the change of serum procalcitonin（ PCT）, interleukin-6（ IL-6 ）, D-D dimer levels in children with Kawasaki disease （KD）, and study the clinical significance of detection. Methods： Thirty children with acute phase KD selected from November 2012 to October 2013 in our hospital were divided into coronary artery disease （CAL） group and non-coronary artery disease （NCAL） group according to echocardiography, each group involved 15 cases. Every one detected serum PCT, IL-6, D-D dimer levels before and after intravenous gamma globulin （IVIG） treatment. Then 30 children of healthy volunteers selected as normal control group. The level of serum PCT was detected by electrochemiluminescence immunoassay, IL-6 was measured by enzyme-linked immunosorbent assay, D-D dimer was determined by immunoturbidimetry. Results ： The levels of PCT, IL-6, D-D dimmer in KD children before IVIG treatment were significantly higher than those after treatment and higher than those in the control group （P〈0. 01 ）, The levels of PCT, 1L-6, D-D dimmer in CAL group were higher than NCAL group （P〈0. 05 ）. Conclusion： Levels of PCT, IL-6, D-D dimer can be used as important indicators of diagnosis and early prediction of KD, which are closely related to the level of coronary artery lesions.

关 键 词：川崎病 白细胞介素 降钙素原 D—D二聚体 冠状动脉 

分 类 号：R725.4[医药卫生—儿科]