益气化瘀、凉血豁痰法治疗混合性中风失语症的临床观察  

Clinical Observation of Nourishing Qi,Resolving Stagnation,Cooling Blood and Eliminating Phlegm Method in Treating Aphasia of Mixed Stroke

作　　者：王明哲[1] 张亮[2] 姜文斐[1] 潘卫东[1] 姜宏宁[3] 

机构地区：[1]上海中医药大学附属曙光医院神经内科,上海201203 [2]上海市第七人民医院神经内科,上海200137 [3]上海中医药大学附属曙光医院放射科,上海201203

出　　处：《上海中医药大学学报》2015年第3期23-26,30,共5页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81373619)

摘　　要：目的:观察具有益气化瘀、凉血豁痰功效的脑血疏口服液结合西医常规疗法治疗混合性中风失语症的临床疗效。方法:将102例伴有失语症的混合性中风患者随机分为治疗组(n=51)和对照组(n=51)。所有患者均采用西医常规疗法治疗,治疗组患者加服脑血疏口服液,治疗周期为4周。采用西方失语成套测验(western aphasia battery,WAB)评价患者的失语症状,采用改良Rankin评分量表(modified Rankin scale,mRS)及美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评价患者的神经功能,检测并比较患者的血液流变学指标的变化。结果:1WAB评分:治疗2周末,治疗组患者的听理解、复述、阅读、计算评分即显著升高(P<0.05);治疗4周末,治疗组患者的听理解、复述、命名、阅读、计算及书写评分均显著升高(P<0.05,P<0.01),对照组患者的听理解、阅读评分亦显著升高(P<0.05),且治疗组患者的各项评分均高于对照组(P<0.05)。2mRS评分:治疗2周末,治疗组患者的mRS评分分级较治疗前显著改善(P<0.05);治疗4周末,两组患者的mRS评分分级较治疗前均显著改善(P<0.05,P<0.01),且治疗组患者的mRS评分分级情况优于对照组(P<0.05)。3NIHSS评分:治疗2周末、4周末,两组患者的NIHSS评分均显著降低(P<0.05,P<0.01),且治疗组患者的评分低于对照组(P<0.05,P<0.01)。4血液流变学指标:治疗4周末,治疗组患者的各项血液流变学指标较治疗前均显著降低(P<0.05,P<0.01),且较对照组亦显著降低(P<0.05)。结论:益气化瘀、凉血豁痰法结合西医常规疗法能够有效改善混合性中风失语症患者的失语症状,在一定程度上改善患者的神经功能和血液流变学指标。Objective： To observe the clinical effect of ＂Naoxueshu Oral Liquid＂ which has the effect of nourishing qi, resolving stagnation, cooling blood and eliminating phlegm combined with conventional westem medical therapy in treating aphasia of mixed stroke. Methods： One hundred and two patients with aphasia of mixed stroke were randomly divided into treatment group （ n = 51） and control group （ n = 51 ）. All the patients were treated With conventional western medical therapy, and the patients in the treatment group were added with ＂Naoxueshu Oral Liquid＂, with a course of 4 weeks. The aphasia was evaluated by western aphasia battery （ WEB）, the neurological function was assessed by modified Rankin scale （mRS） and National Institutes of Health Stroke Scale （NIHSS）, and the hemorbeol0gy indexes were detected before and after treatment. Resuits：①WEB scores： Two weeks after treatment, the scores of comprehension, rehearsal, reading and calculating in the treatment group were increased （ P 〈 0.05 ） ; four weeks after treatment, the scores of comprehension, rehearsal, naming, reading, calculating and writing in the treatment group were increased （ P 〈 0.05, P 〈 0.01 ） , the scores of comprehension and reading in the control group were also increased （ P 〈 0.05 ）, and the scores of all the items of the treatment group were higher than those of the control group （ P 〈 0.05 ）. ②mRS scores ： Two weeks after treatment, the score grade of mRS in the treatment group was improved （ P 〈 0.05 ） ; four weeks after treatment, the score grade of mRS in both groups was improved （ P 〈 0.05, P 〈 0.01 ）, and the score grade of mRS in the treatment group was better than that in the control group （ P 〈0.05 ）. ③NII-ISS scores ： Two weeks and four weeks after treatment, the NIHSS scores of both groups were decreased （ P 〈 0.05, P 〈 0.01 ）, and the scores of the treatment group were lower than those of the control group （ P 〈 0.05, P 〈 0.01

关 键 词：混合性中风 失语症 益气化瘀、凉血豁痰法 西方失语成套测验 改良Rankin评定量表 

分 类 号：R277.7[医药卫生—中医学]