益气活血化痰方早期干预老年无症状期下肢动脉粥样硬化的临床观察  

Study on clinical effect of “Yiqi Huoxue Huatan Decoction”on the early intervention period of asymptomatic atherosclerosis of the lower extremities

作　　者：李欣[1] 陈咸川[1] 马绍骏[2] 沈融[1] 

机构地区：[1]上海中医药大学附属岳阳中西医结合医院老年科,上海200437 [2]上海交通大学医学院附属第九人民医院老年病科,上海200011

出　　处：《上海中医药杂志》2015年第6期35-38,共4页Shanghai Journal of Traditional Chinese Medicine

基　　金：上海中医药大学附属岳阳中西医结合医院院级课题(30304115272)

摘　　要：目的观察益气活血化痰方治疗老年无症状期下肢动脉粥样硬化的临床疗效。方法将70例老年无症状期下肢动脉粥样硬化患者随机分为治疗组和对照组,每组35例。对照组予辛伐他汀,治疗组在对照组治疗措施基础上加用益气活血化痰方。两组疗程均为12周,观察中医证候积分、ABI及IMT水平的变化情况。结果 1治疗前后组内比较,两组中医证候积分差异有统计学意义(P<0.05);组间治疗前后中医证候积分差值比较,差异有统计学意义(P<0.05)。2治疗前后组内比较,治疗组ABI水平、IMT厚度差异有统计学意义(P<0.05);组间治疗前后ABI水平、IMT厚度的差值比较,差异有统计学意义(P<0.05)。结论益气活血化痰方治疗老年无症状期下肢动脉粥样硬化,可显著改善患者血管弹性及下肢功能不全,延缓下肢动脉粥样硬化进程。Objective This paper is to observe the clinical effect of the treatment with ＂Yiqi Huoxue Huatan Decoction＂on senile patients of low extremity atherosclerotic disease（ LEAD） of asymptomatic period.Methods 70 cases of aged patients with asymptomatic LEAD were randomly divided into treatment group and control group,and there are 35 cases in each group.The control group was given Simvastatin and the treatment group was added using of＂Yiqi Huoxue Huatan Decoctionin＂on the basis of the control group.The course of treatment of the both groups was 12 weeks.The changes of clinical symptoms,ABI and IMT were observed during the course.Results ① Compared before and after the treatment,the difference of clinical symptoms of TCM in both groups were statistically significant（ P〈0.05）;compared after treatment of the two groups,the D-value of clinical symptoms of TCM were statistically significant（ P〈0.05）.②Compared before and after treatment,the difference in the level of ABI and the thickness of IMT were statistically significant（ P〈0.05）;compared after treatment between the two groups,the D-value of level of ABI and thickness of IMT was statistically（ P〈0.05）.Conclusion The treatment of the early intervention period of asymptomatic atherosclerosis of the lower extremities by＂Yiqi Huoxue Huatan Decoction＂can significantly improved vascular elasticity and polish up Lower limb function of patients,and can delay the progress of LEAD.

关 键 词：下肢动脉粥样硬化 无症状期 益气活血化痰方 踝臂指数 股动脉内-中膜厚度 

分 类 号：R259[医药卫生—中西医结合]