先兆流产孕妇血清PIBF(孕激素诱导的阻断因子)水平的表达及黄体酮治疗对其的影响  

Expression of Progesterone-induced Blocking Factor(PIBF) and Effection of Progesterone to the Level of it in Serum of Patients with Spontaneous abortion

作　　者：彭君醒 杨小芳[1] 叶国娟 易旺云[1] 袁明生[1] 

机构地区：[1]广东省中山市陈星海医院妇产科,中山528415

出　　处：《海峡药学》2015年第5期86-88,共3页Strait Pharmaceutical Journal

摘　　要：目的通过检测先兆流产患者用黄体酮治疗前后血清中孕酮(P)和孕激素诱导的阻断因子(PIBF)的表达水平,探讨PIBF的临床意义及与P的相关关系。方法选取70例正常早孕妇为对照组,辅以常规安胎处置,70例早期先兆流产者为实验组,除常规处置外加用黄体酮治疗,检测处置前后两组血清中P及PIBF的浓度,分析相关性。结果治疗前实验组的血清PIBF水平明显低于对照组(P<0.05),而治疗后实验组的血清PIBF水平逐渐提升至与对照组相近(P>0.05);治疗前实验组的P浓度远低于对照组(P<0.05),治疗后实验组血清P浓度提升到甚至超过对照组水平;对照组血清P及PIBF呈正相关(r=0.376,P<0.01),但实验组中血清P及PIBF浓度又不具备显著相关关系(r=0.212,P>0.05);结论血清PIBF水平的检测能为早期先兆流产使用黄体酮治疗提供实验室依据,帮助预测妊娠的结局,值得推广。OBJECTIVE To investigate the expression and clinical significance of progesterone（ P） and proges-terone-induced blocking factor（ PIBF） in serum of patients with spontaneous abortion before and after the progester-one therapy.METHODS The 70 cases of healthy pregnant women were chosen as control group and received Con-ventional treatment,while the other 70 patients with spontaneous abortion were selected as experimental group,treated as the control group but joint progesterone.The PIBF and P concentrations in serum of 2 groups were measured and the results were analysed;RESULTS PIBF and P in serum of experimental group were lower than those in control group before the treatment （ P〈0.05 ）.PIBF was close to and P was even higher than the control group after the treatment.In contrast with control group.no linear correlation was found between the serum P and PIBF expressions in the exprimental groups（P〉0.05）.CONCLUSION Detection of serum PIBF for early threatened abortion can provide laboratory evidence for progesterone treatment,predicting the outcome of pregnancy,and worth promotion.

关 键 词：先兆流产 黄体酮 孕激素诱导的阻断因子 

分 类 号：R969.4[医药卫生—药理学]