电针对体外受精-胚胎移植结局及卵巢过度刺激综合征发生的影响  

Influence of electro-acupuncture on the occurrence of ovarian hyper-stimulation syndrome and outcome of in vitro fertilization and embryo transplantation

作　　者：洪艳丽[1] 谈勇[2] 殷燕云[1] 邹奕洁[1] 郭银华[1] 聂小伟[1] 

机构地区：[1]南京中医药大学附属江苏省中医院,南京210029 [2]南京中医药大学第一临床医学院,南京210046

出　　处：《中华中医药杂志》2015年第6期2110-2113,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：江苏省中医药管理局科技项目(No.LZ13002);江苏省研究生培养创新工程(No.2010457);江苏省高校优势学科建设工程资助项目(No.YS2012ZYX413)~~

摘　　要：目的:观察电针在辅助生殖中对临床结局的影响。方法:将接受长方案体外受精-胚胎移植(IVFET)助孕患者随机分为观察组和对照组。观察组从使用促性腺激素(Gn)日开始至胚胎移植(ET)日接受电针治疗。检测两组人绒促性素(h CG)注射日、穿刺取卵(OPU)日、ET日血清雌二醇(E2)及血管内皮生长因子(VEGF)、白细胞介素-6(IL-6)、血管紧张素Ⅱ(AT-Ⅱ)水平。比较两组临床结局及卵巢过度刺激综合征(OHSS)发生率。结果:与对照组比较,观察组E2在OPU日、ET日均明显降低(P<0.05);OPU日,卵泡液VEGF、IL-6水平亦明显降低(P<0.05)。两组患者血清VEGF、IL-6均在h CG日水平最高,随后呈下降趋势;与对照组比较,观察组h CG日、OPU日、ET日血清VEGF、IL-6均明显降低(P<0.05)。观察组移植周期取消率、OHSS发生率均明显低于对照组(P<0.05)。结论:电针辅助能有效防治IVF过程中OHSS发生,且不降低IVF优胚率及妊娠率,可能与其降低患者卵巢局部血管通透性有关。Objective： To observe the effect of electro-acupuncture on the clinical outcome in assisted reproduction. Methods： Patients will accept long-term plan of in vitro fertilization and embryo transfer were randomly divided into control group and treatment group. Patients in treatment group were treated with electro-acupuncture from the day of Gn injection to the ET day. The levels of E2, VEGF, IL-6 and AT-II of patients in the two groups were tested on the hCG day, ovum pick up （OPU） day and embryo transfer （ET） day. The clinical outcome occurrence of ovarian hyper-stimulation syndrome （OHSS） of the two groups was compared. Results： Compared with control group, the serum E2 levels of patients in treatment group on the OPU day and ET day were significantly decreased, and the differences between the two groups was statistically significant （P〈0.05）. On the OPU day, the levels of VEGF and IL-6 in ovarian follicular fluid in patients of treatment group were significantly lower than that of control group （P〈0.05）. The levels of VEGF and IL-6 of patients in the two groups on the hCG day were the highest, then kept followed by a downward trend. Compared with the control group, the levels of VEGF and IL-6 in serum of patients in treatment group were decreased significantly on the hCG day, OPU day and ET day （P〈0.05）. The transplant cycle cancellation rate and occurrence rate of OHSS in treatment group were significantly lower than that in control group （P〈0.05）. Conclusion： Electro-acupuncture assisted therapy could prevent the occurrence of OHSS in the process of IVF and could not reduce the high qualified embryo rate of IVF and pregnancy rate, which might be relate to the decreasing of vascular permeability in patients＇ ovarian local.

关 键 词：电针 体外受精-胚胎移植 卵巢过度刺激综合征 血管通透性 

分 类 号：R714.8[医药卫生—妇产科学]