益生菌结合行为干预对肠易激综合征病人免疫功能的影响分析  

Analysis of influence of probiotics combined with behavioral intervention on immune function of patients with irritable bowel syndrome

作　　者：高宇[1] 谢明水[2] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院 [2]湖北省随州市中心医院

出　　处：《护理研究（上旬版）》2015年第6期1942-1945,共4页Chinese Nursing Researsh

基　　金：湖北省科技厅项目;编号:2013CFB480

摘　　要：[目的]探讨益生菌结合行为干预对肠易激综合征病人免疫功能的影响。[方法]将120例肠易激综合征病人根据随机抽签原则分为治疗组与对照组各60例,两组均给予基于益生菌的治疗方案,对照组给予常规护理,治疗组给予积极的行为干预,干预周期为2个月。[结果]干预后治疗组有效率为96.7%,对照组有效率为95.0%,两组有效率比较差异无统计学意义(P>0.05);干预后两组血清CD_8^+值明显下降,CD_4^+值明显升高(P<0.05),且治疗组血清CD_8^+和CD_4^+值与对照组比较差异有统计学意义(P<0.05);两组干预后焦虑与抑郁评分明显低于干预前,且干预后治疗组焦虑与抑郁评分明显低于对照组(P<0.05);干预后治疗组生理功能、生理职能、躯体疼痛和总体健康评分明显高于对照组(P<0.05)。[结论]益生菌治疗肠易激综合征具有较好的疗效,而行为干预的应用能促进免疫功能的提高,缓解焦虑与抑郁情绪,从而提高病人的生活质量。Objective：To probe into the influence of probiotics combined with behavioral intervention on the im-mune function of patients with irritable bowel syndrome.Methods：A total of 120 cases of patients with irritable bowel syndrome were divided into treatment group and control group according to the principle of random lot-tery,60 cases in each.The patients in both groups were given the treatment plan based on probiotics.The pa-tients in control group were given conventional nursing,but the patients in treatment group were given the posi-tive behavioral interventions,and the intervention circle period was 2 months.Results：The effective rate of treat-ment group after intervention was 9 6 .7%,and that in control group was 9 5 .0%,and there was no statistically significant difference in efficient rate between both groups（P〉0.05）.After the intervention,the CD8 ＋ value in serum levels in both groups decreased significantly,CD4 ＋ value increased significantly（P〈0.05）,and there was statistically significant difference in serum value of CD8 ＋ and CD4 ＋ after the intervention between both groups （P〈0.05）;after the intervention,anxiety and depression scores in two groups were significantly lower than that before intervention.The anxiety and depression scores in treatment group after the intervention were muen lower than that in control group（P〈0.05）.After the intervention,the scores of physiological function,physio-logical functions,physical pain and general health scores in treatment group were significantly higher than that in control group（P〈0.05）.Conclusion：Probiotics for treatment of patients with irritable bowel syndrome has good curative effect,and the application of behavioral intervention can improve the immunity function,relieve anxiety and depression,and then to enhance the patients’quality of life.

关 键 词：肠易激综合征 益生菌 行为干预 免疫功能 

分 类 号：R473.5[医药卫生—护理学]